5TRF

MDM2 in complex with SAR405838

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
B	0005634	cellular_component	nucleus
B	0043066	biological_process	negative regulation of apoptotic process
B	0051726	biological_process	regulation of cell cycle
C	0005634	cellular_component	nucleus
C	0043066	biological_process	negative regulation of apoptotic process
C	0051726	biological_process	regulation of cell cycle
D	0005634	cellular_component	nucleus
D	0043066	biological_process	negative regulation of apoptotic process
D	0051726	biological_process	regulation of cell cycle
E	0005634	cellular_component	nucleus
E	0043066	biological_process	negative regulation of apoptotic process
E	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue 7HC A 201

Chain	Residue
A	THR10
A	TYR67
A	VAL93
A	LYS94
A	HIS96
A	ILE99
A	TYR100
A	VAL14
A	THR16
A	LEU54
A	GLY58
A	GLN59
A	ILE61
A	MET62
A	MET62

---

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 202

Chain	Residue
A	LYS45
A	ASP46
A	THR47

---

site_id	AC3
Number of Residues	6
Details	binding site for residue GOL A 203

Chain	Residue
A	TYR104
A	VAL109
A	HOH304
A	HOH310
A	HOH313
A	HOH342

---

site_id	AC4
Number of Residues	6
Details	binding site for residue GOL A 204

Chain	Residue
A	ARG105
A	HOH334
B	GLY87
B	ARG105
C	ARG105
D	ARG105

---

site_id	AC5
Number of Residues	9
Details	binding site for residue GOL A 205

Chain	Residue
A	ASP84
A	LEU85
A	ARG105
A	HOH309
C	HOH313
D	LYS31
D	TYR104
D	ARG105
D	LEU107

---

site_id	AC6
Number of Residues	15
Details	binding site for residue 7HC B 201

Chain	Residue
B	VAL14
B	THR16
B	LEU54
B	GLY58
B	ILE61
B	MET62
B	TYR67
B	VAL93
B	HIS96
B	ILE99
B	TYR100
B	GOL203
D	THR10
D	GLN59
D	MET62

---

site_id	AC7
Number of Residues	8
Details	binding site for residue GOL B 202

Chain	Residue
B	ALA13
B	VAL14
B	THR15
B	LYS51
B	HOH335
D	ALA13
D	THR15
D	LYS51

---

site_id	AC8
Number of Residues	6
Details	binding site for residue GOL B 203

Chain	Residue
B	PHE55
B	GLY58
B	GLN59
B	7HC201
B	HOH301
D	7HC201

---

site_id	AC9
Number of Residues	14
Details	binding site for residue 7HC C 201

Chain	Residue
C	VAL14
C	THR16
C	LEU54
C	LEU57
C	GLY58
C	GLN59
C	ILE61
C	TYR67
C	PHE86
C	VAL93
C	LYS94
C	HIS96
C	ILE99
C	TYR100

---

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 C 202

Chain	Residue
C	LYS45
C	ASP46
C	THR47

---

site_id	AD2
Number of Residues	6
Details	binding site for residue GOL C 203

Chain	Residue
C	LYS98
C	THR101
C	HOH301
C	HOH313
C	HOH321
C	HOH332

---

site_id	AD3
Number of Residues	6
Details	binding site for residue GOL C 204

Chain	Residue
A	ILE74
A	PHE91
A	SER92
C	TYR76
C	SER78
C	PRO89

---

site_id	AD4
Number of Residues	12
Details	binding site for residue 7HC D 201

Chain	Residue
D	VAL14
D	THR16
D	LEU54
D	GLY58
D	ILE61
D	MET62
D	VAL93
D	HIS96
D	ILE99
D	TYR100
B	GLN59
B	GOL203

---

site_id	AD5
Number of Residues	13
Details	binding site for residue 7HC E 201

Chain	Residue
E	THR10
E	VAL14
E	THR16
E	LEU54
E	GLY58
E	ILE61
E	MET62
E	TYR67
E	HIS73
E	VAL93
E	HIS96
E	ILE99
E	TYR100

---

site_id	AD6
Number of Residues	3
Details	binding site for residue SO4 E 202

Chain	Residue
E	LYS45
E	ASP46
E	THR47

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	166
Details	Domain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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