6I29

X-ray structure of the p53-MDM2 inhibitor NMI801 bound to HDM2 at 2.1A resolution

Summary for 6I29

• Entry DOI: 10.2210/pdb6i29/pdb
• Related: 4DIJ
• Descriptor: Human E3 Ubiquitin-Protein Ligase MDM2, 6-chloranyl-3-[3-[(1~{S})-1-(4-chlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-~{N}-[2-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]pyridin-3-yl]-1~{H}-indole-2-carboxamide (3 entities in total)
• Functional Keywords: lead optimization, ligase
• Biological source: Homo Sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 11890.73

Authors

Kallen, J. (deposition date: 2018-11-01, release date: 2019-11-20, Last modification date: 2024-01-24)

• Primary citation: Ornstein, J.,Iwamoto, Y.,Prytyskach, M.,Miller, M.,Kallen, J.,Ferretti, S.,Holzer, P.,Forrester, W.,Weissleder, R.,Lahav, G.; p53 dynamics vary between tissues and are linked with radiation sensitivity; To be published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)