4DIJ

The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction

Summary for 4DIJ

• Entry DOI: 10.2210/pdb4dij/pdb
• Related: 1YCR
• Descriptor: E3 ubiquitin-protein ligase Mdm2, 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide (3 entities in total)
• Functional Keywords: ppi with p53, ppi inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 2
• Total formula weight: 23493.02

Authors

Kallen, J. (deposition date: 2012-01-31, release date: 2012-05-02, Last modification date: 2024-04-03)

• Primary citation: Furet, P.,Chene, P.,De Pover, A.,Valat, T.S.,Lisztwan, J.H.,Kallen, J.,Masuya, K.; The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction.; Bioorg.Med.Chem.Lett., 22:3498-3502, 2012; PubMed: 22507962; DOI: 10.1016/j.bmcl.2012.03.083

Experimental method

X-RAY DIFFRACTION (1.9 Å)