6I29
X-ray structure of the p53-MDM2 inhibitor NMI801 bound to HDM2 at 2.1A resolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Human E3 Ubiquitin-Protein Ligase MDM2 | polymer | 96 | 11156.1 | 1 | UniProt (Q00987) Pfam (PF02201) In PDB | Homo Sapiens (human) | |
| 2 | A | 6-chloranyl-3-[3-[(1~{S})-1-(4-chlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-~{N}-[2-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]pyridin-3-yl]-1~{H}-indole-2-carboxamide | non-polymer | 734.7 | 1 | Chemie (H0W) | |||
| 3 | water | water | 18.0 | 45 | Chemie (HOH) |
Sequence modifications
A: 17 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11156.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 734.7 | |
| All* | Total formula weight | 11890.7 |
