5SWK

Crystal structure of p53 epitope-scaffold based on a inhibitor of cysteine proteases in complex with human MDM2

Summary for 5SWK

Entry DOI	10.2210/pdb5swk/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, De novo protein based on the inhibitor Amoebiasin-1, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	peptidomimetics, biosensor, scaffold, designed, de novo protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	59083.99
Authors	Jimenez-Sandoval, P.,Brieba, L.G. (deposition date: 2016-08-08, release date: 2017-10-18, Last modification date: 2023-10-04)
Primary citation	Jimenez-Sandoval, P.,Madrigal-Carrillo, E.A.,Santamaria-Suarez, H.A.,Maturana, D.,Renteria-Gonzalez, I.,Benitez-Cardoza, C.G.,Torres-Larios, A.,Brieba, L.G. Mimicking a p53-MDM2 interaction based on a stable immunoglobulin-like domain scaffold. Proteins, 86:802-812, 2018 Cited by PubMed: 29696695 DOI: 10.1002/prot.25519 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.923 Å)

Structure validation