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5SWK

Crystal structure of p53 epitope-scaffold based on a inhibitor of cysteine proteases in complex with human MDM2

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
E3 ubiquitin-protein ligase Mdm2polymer15317237.52UniProt (Q00987)
Pfam (PF02201)
Homo sapiens (Human)Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2
2C, D
(C, D)
De novo protein based on the inhibitor Amoebiasin-1polymer11012038.32Entamoeba histolyticaCysteine protease inhibitor 1,EhICP1,ICP-1
3E, F, H, I, J...
(A, B, D)
CHLORIDE IONnon-polymer35.57Chemie (CL)
4G, L
(B, C)
SULFATE IONnon-polymer96.12Chemie (SO4)
5N
(D)
GLYCEROLnon-polymer92.11Chemie (GOL)
6O, P, Q, R
(A, B, C, D)
waterwater18.0157Chemie (HOH)
Sequence modifications
A, B: 1 - 150 (UniProt: Q00987)
PDBExternal DatabaseDetails
Gly -2-expression tag
Pro -1-expression tag
His 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight58551.6
Non-Polymers*Number of molecules10
Total formula weight532.4
All*Total formula weight59084.0
*Water molecules are not included.

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PDB entries from 2024-10-30

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