5SWK
Crystal structure of p53 epitope-scaffold based on a inhibitor of cysteine proteases in complex with human MDM2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase Mdm2 | polymer | 153 | 17237.5 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (Human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,p53-binding protein Mdm2 |
| 2 | C, D (C, D) | De novo protein based on the inhibitor Amoebiasin-1 | polymer | 110 | 12038.3 | 2 | Entamoeba histolytica | Cysteine protease inhibitor 1,EhICP1,ICP-1 | |
| 3 | E, F, H, I, J... (A, B, D) | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) | |||
| 4 | G, L (B, C) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | N (D) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | O, P, Q, R (A, B, C, D) | water | water | 18.0 | 157 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 150 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly -2 | - | expression tag |
| Pro -1 | - | expression tag |
| His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 58551.6 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 532.4 | |
| All* | Total formula weight | 59084.0 |
