5SWK

Crystal structure of p53 epitope-scaffold based on a inhibitor of cysteine proteases in complex with human MDM2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
B	0005634	cellular_component	nucleus
B	0043066	biological_process	negative regulation of apoptotic process
B	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CL A 201

Chain	Residue
A	LYS45
A	ASP46
A	THR47

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site_id	AC2
Number of Residues	2
Details	binding site for residue CL A 202

Chain	Residue
A	GLN71
A	HIS73

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site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 B 201

Chain	Residue
B	LYS98
B	LYS94
B	GLU95
B	HIS96
B	ARG97

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site_id	AC4
Number of Residues	2
Details	binding site for residue CL B 202

Chain	Residue
B	ASP46
B	THR47

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site_id	AC5
Number of Residues	2
Details	binding site for residue CL B 203

Chain	Residue
B	MET62
B	HOH329

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site_id	AC6
Number of Residues	2
Details	binding site for residue CL B 204

Chain	Residue
B	GLU95
B	LYS98

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site_id	AC7
Number of Residues	2
Details	binding site for residue CL B 205

Chain	Residue
B	GLN71
B	HIS73

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site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 C 201

Chain	Residue
C	GLU40
C	GLY41
D	GLY41
D	HOH302
D	HOH325

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site_id	AC9
Number of Residues	1
Details	binding site for residue CL D 201

Chain	Residue
D	THR11

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site_id	AD1
Number of Residues	4
Details	binding site for residue GOL D 202

Chain	Residue
C	THR73
D	LYS16
D	GLN72
D	THR73

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	83
Details	Domain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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