PDB: 155 resultsInfo pagesStatus searchChemie searchBIRD

---

4UE1	Structure of the stapled peptide YS-01 bound to MDM2 Descriptor: E3 UBIQUITIN-PROTEIN LIGASE MDM2, YS-01 Authors: Tan, Y.S, Reeks, J, Brown, C.J, Jennings, C.E, Eapen, R.S, Tng, Q.S, Thean, D, Ying, Y.T, Gago, F.J.F, Lane, D.P, Noble, M.E.M, Verma, C. Deposit date: 2014-12-14 Release date: 2016-01-13 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design. J Phys Chem Lett, 7, 2016
5TRF	MDM2 in complex with SAR405838 Descriptor: (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2, GLYCEROL, ... Authors: Meagher, J.L, Stuckey, J.A. Deposit date: 2016-10-26 Release date: 2016-11-09 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression. Cancer Res., 74, 2014
5VK0	Crystal structure of human MDM2 in complex with a 12-mer lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, Lysine-cysteine side chain dithiocarbamate stapled peptide inhibitor PMI Authors: Tolbert, W.D, Gohain, N, Pazgier, M. Deposit date: 2017-04-20 Release date: 2018-04-25 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Dithiocarbamate-inspired side chain stapling chemistry for peptide drug design. Chem Sci, 10, 2019
8AEU	Structure of hMDM2 in complex with Nutlin-3a-aa Descriptor: 4-[[(4~{S},5~{R})-4,5-bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxy-phenyl)-4,5-dihydroimidazol-1-yl]carbonyl]-3-methylidene-piperazin-2-one, BETA-MERCAPTOETHANOL, E3 ubiquitin-protein ligase Mdm2 Authors: Labuzek, B, Golik, P, Magiera-Mularz, K, Berg, T. Deposit date: 2022-07-13 Release date: 2023-01-18 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Nutlin-3a-aa: Improving the Bioactivity of a p53/MDM2 Interaction Inhibitor by Introducing a Solvent-Exposed Methylene Group. Chembiochem, 24, 2023
6T2F	Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions Descriptor: 2-(methylamino)-~{N}-[[3-[[2-(methylamino)ethanoylamino]methyl]phenyl]methyl]ethanamide, E3 ubiquitin-protein ligase Mdm2, MDM2 in complex with GAR300-Am Authors: Groves, R.M, Ali, M.A, Atmaj, J, van Oosterwijk, N, Domling, A, Rivera, G.D, Ricardo, G.M. Deposit date: 2019-10-08 Release date: 2020-01-29 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 59, 2020
6T2E	Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions Descriptor: E3 ubiquitin-protein ligase Mdm2, Stapled peptide GAR300-Gm Authors: Groves, R.M, Ali, M.A, Atmaj, J, van Oosterwijk, N, Domling, A, Rivera, G.D, Ricardo, G.M. Deposit date: 2019-10-08 Release date: 2020-01-29 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 59, 2020
2MPS	Structure of complex of MDM2(3-109) and P73 TAD(10-25) Descriptor: E3 ubiquitin-protein ligase Mdm2, Tumor protein p73 Authors: Shin, J.S, Ha, J.H, Chi, S.W. Deposit date: 2014-06-02 Release date: 2015-06-03 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition Cell Cycle, 14, 2015
6T2D	Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions Descriptor: 2-(methylamino)-~{N}-[[4-[[2-(methylamino)ethanoylamino]methyl]phenyl]methyl]ethanamide, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DIMETHYL SULFOXIDE, ... Authors: Groves, R.M, Ali, M.A, Atmaj, J, van Oosterwijk, N, Domling, A, Rivera, G.D, Ricardo, G.M. Deposit date: 2019-10-08 Release date: 2020-01-29 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions. Angew.Chem.Int.Ed.Engl., 59, 2020
5XXK	Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids Descriptor: E3 ubiquitin-protein ligase Mdm2, Hydrocarbon stapled peptide THC-SER-PHE-0EH-GLU-TYR-6CW-ALA-LEU-LEU-MK8-NH2 Authors: Brown, C.J. Deposit date: 2017-07-04 Release date: 2017-12-27 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.66 Å) Cite: Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids. PLoS ONE, 12, 2017
1Z1M	NMR structure of unliganded MDM2 Descriptor: Ubiquitin-protein ligase E3 Mdm2 Authors: Uhrinova, S, Uhrin, D, Powers, H, Watt, K, Zheleva, D, Fischer, P, McInnes, C, Barlow, P.N. Deposit date: 2005-03-04 Release date: 2005-06-28 Last modified: 2022-03-02 Method: SOLUTION NMR Cite: Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments that Accompany p53-binding J.Mol.Biol., 350, 2005
5UMM	CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH 12-MER PEPTIDE INHIBITOR M3 Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, PEPTIDE INHIBITOR M3 Authors: Pazgier, M, Gohain, N, Tolbert, W.D. Deposit date: 2017-01-27 Release date: 2018-01-31 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for p53 activation To Be Published
4ERE	crystal structure of MDM2 (17-111) in complex with compound 23 Descriptor: E3 ubiquitin-protein ligase Mdm2, SULFATE ION, [(3R,5R,6S)-1-[(2S)-1-tert-butoxy-1-oxobutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl]acetic acid Authors: Huang, X. Deposit date: 2012-04-20 Release date: 2012-05-23 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structure-based design of novel inhibitors of the MDM2-p53 interaction. J.Med.Chem., 55, 2012
6V4E	Crystal Structure Analysis of Zebra Fish MDM Descriptor: Protein Mdm4, Stapled peptide QSQQTF(0EH)NLWRLL(MK8)QN(NH2) Authors: Seo, H.-S, Dhe-Paganon, S. Deposit date: 2019-11-27 Release date: 2020-04-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.62 Å) Cite: Identification of a Structural Determinant for Selective Targeting of HDMX. Structure, 28, 2020
6V4G	Crystal Structure Analysis of Zebra fish MDMX Descriptor: Protein Mdm4, SULFATE ION, Stapled peptide QSQQTF(0EH)NLWRLE(MK8)QN(NH2) Authors: Seo, H.-S, Dhe-Paganon, S. Deposit date: 2019-11-27 Release date: 2020-04-22 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (1.25 Å) Cite: Identification of a Structural Determinant for Selective Targeting of HDMX. Structure, 28, 2020
3IWY	Crystal structure of human MDM2 complexed with D-peptide (12 residues) Descriptor: D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2 Authors: Pazgier, M, Lu, W. Deposit date: 2009-09-03 Release date: 2010-04-21 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (1.93 Å) Cite: D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms. Proc.Natl.Acad.Sci.USA, 398, 2010
4HG7	Crystal Structure of an MDM2/Nutlin-3a complex Descriptor: 4-({(4S,5R)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazol-1-yl}carbonyl)piperazin-2-one, E3 ubiquitin-protein ligase Mdm2, SULFATE ION Authors: Noble, M.E.M, Anil, B, Riedinger, C, Endicott, J.A. Deposit date: 2012-10-07 Release date: 2013-07-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.6 Å) Cite: The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant. Acta Crystallogr.,Sect.D, 69, 2013
3IUX	Crystal structure of human MDM2 in complex with a potent miniature protein inhibitor (18-residues) Descriptor: ACETATE ION, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... Authors: Pazgier, M, Lu, W. Deposit date: 2009-08-31 Release date: 2009-10-27 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Apamin as a template for structure-based rational design of potent peptide activators of p53. Angew.Chem.Int.Ed.Engl., 48, 2009
6Q9L	HDM2 (17-111, WILDTYPE) COMPLEXED WITH COMPOUND 9 AT 1.13A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, [6-chloranyl-3-[3-[[4-chloranyl-2-(hydroxymethyl)phenyl]methyl]-5-phenyl-imidazol-4-yl]-1~{H}-indol-2-yl]-[(3~{S})-3-[3-(dimethylamino)propyl-methyl-amino]pyrrolidin-1-yl]methanone Authors: Kallen, J. Deposit date: 2018-12-18 Release date: 2019-05-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.13 Å) Cite: Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
6Q9O	HDM2 (17-111, WILDTYPE) COMPLEXED WITH COMPOUND 10 AT 1.21A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes Descriptor: E3 ubiquitin-protein ligase Mdm2, ~{N}-~{tert}-butyl-2-[4-chloranyl-2-[5-(3-chloranyl-4-fluoranyl-phenyl)-2-cyclohexyl-4-(1~{H}-1,2,3,4-tetrazol-5-yl)imidazol-1-yl]phenyl]ethanamide Authors: Kallen, J. Deposit date: 2018-12-18 Release date: 2019-05-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.21 Å) Cite: Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
6Q9H	HDM2 (17-111, WILD TYPE) COMPLEXED WITH COMPOUND 11 AT 2.0A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes Descriptor: (4~{S})-5-(3-chloranyl-2-fluoranyl-phenyl)-4-(4-chloranyl-2-methyl-phenyl)-3-propan-2-yl-1,4-dihydropyrrolo[3,4-c]pyrazol-6-one, E3 ubiquitin-protein ligase Mdm2 Authors: Kallen, J. Deposit date: 2018-12-18 Release date: 2019-05-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
6Q96	HDM2 (17-111, WILD TYPE) COMPLEXED WITH COMPOUND 12 AT 1.8A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes Descriptor: 4-[(4~{S})-5-(5-chloranyl-2-oxidanylidene-1~{H}-pyridin-3-yl)-2-[2-(dimethylamino)-4-methoxy-pyrimidin-5-yl]-6-oxidanylidene-3-propan-2-yl-4~{H}-pyrrolo[3,4-c]pyrazol-4-yl]benzenecarbonitrile, E3 ubiquitin-protein ligase Mdm2, SULFATE ION Authors: Kallen, J. Deposit date: 2018-12-17 Release date: 2019-05-15 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14, 2019
3JZS	Human MDM2 liganded with a 12mer peptide inhibitor (pDIQ) Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase Mdm2, pDIQ peptide (12mer) Authors: Schonbrunn, E, Phan, J. Deposit date: 2009-09-24 Release date: 2009-11-10 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.78 Å) Cite: Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285, 2010
3JZK	crystal structure of MDM2 with chromenotriazolopyrimidine 1 Descriptor: (6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine, E3 ubiquitin-protein ligase Mdm2 Authors: Huang, X. Deposit date: 2009-09-23 Release date: 2009-11-17 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J.Med.Chem., 52, 2009
4HBM	Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors Descriptor: E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-2-oxopiperidin-3-yl}acetic acid Authors: Huang, X. Deposit date: 2012-09-28 Release date: 2012-10-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Ordering of the N-terminus of human MDM2 by small molecule inhibitors. J.Am.Chem.Soc., 134, 2012
3LBL	Structure of human MDM2 protein in complex with Mi-63-analog Descriptor: (2'R,3R,4'R,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2 Authors: Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A. Deposit date: 2010-01-08 Release date: 2010-03-16 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9, 2010

<1234567>