3IUX
Crystal structure of human MDM2 in complex with a potent miniature protein inhibitor (18-residues)
Summary for 3IUX
Entry DOI | 10.2210/pdb3iux/pdb |
Related | 1T4E 1YCR 3EQY 3IVJ |
Descriptor | E3 ubiquitin-protein ligase Mdm2, miniature protein inhibitor, ACETATE ION, ... (5 entities in total) |
Functional Keywords | mdm2, p53 binding domain, peptide activator of p53, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation pathway, zinc-finger |
Cellular location | Nucleus, nucleoplasm: Q00987 |
Total number of polymer chains | 4 |
Total formula weight | 24806.53 |
Authors | Pazgier, M.,Lu, W. (deposition date: 2009-08-31, release date: 2009-10-27, Last modification date: 2023-09-06) |
Primary citation | Li, C.,Pazgier, M.,Liu, M.,Lu, W.Y.,Lu, W. Apamin as a template for structure-based rational design of potent peptide activators of p53. Angew.Chem.Int.Ed.Engl., 48:8712-8715, 2009 Cited by PubMed: 19827079DOI: 10.1002/anie.200904550 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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