6Q96
HDM2 (17-111, WILD TYPE) COMPLEXED WITH COMPOUND 12 AT 1.8A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
Summary for 6Q96
Entry DOI | 10.2210/pdb6q96/pdb |
Related | 50C8 |
Descriptor | E3 ubiquitin-protein ligase Mdm2, 4-[(4~{S})-5-(5-chloranyl-2-oxidanylidene-1~{H}-pyridin-3-yl)-2-[2-(dimethylamino)-4-methoxy-pyrimidin-5-yl]-6-oxidanylidene-3-propan-2-yl-4~{H}-pyrrolo[3,4-c]pyrazol-4-yl]benzenecarbonitrile, SULFATE ION, ... (4 entities in total) |
Functional Keywords | lead optimization, ligase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 23594.21 |
Authors | Kallen, J. (deposition date: 2018-12-17, release date: 2019-05-15, Last modification date: 2024-01-24) |
Primary citation | Kallen, J.,Izaac, A.,Chau, S.,Wirth, E.,Schoepfer, J.,Mah, R.,Schlapbach, A.,Stutz, S.,Vaupel, A.,Guagnano, V.,Masuya, K.,Stachyra, T.M.,Salem, B.,Chene, P.,Gessier, F.,Holzer, P.,Furet, P. Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes. Chemmedchem, 14:1305-1314, 2019 Cited by PubMed: 31066983DOI: 10.1002/cmdc.201900201 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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