6Q96
HDM2 (17-111, WILD TYPE) COMPLEXED WITH COMPOUND 12 AT 1.8A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue HRE A 201 |
| Chain | Residue |
| A | LEU54 |
| A | TYR100 |
| A | HOH337 |
| A | HOH348 |
| A | HOH366 |
| B | GLU25 |
| B | THR26 |
| B | TYR100 |
| B | TYR104 |
| B | HOH306 |
| A | GLY58 |
| A | ILE61 |
| A | MET62 |
| A | TYR67 |
| A | GLN72 |
| A | PHE86 |
| A | VAL93 |
| A | HIS96 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 202 |
| Chain | Residue |
| A | ARG97 |
| A | HOH304 |
| A | HOH325 |
| A | HOH361 |
| A | HOH367 |
| B | ARG65 |
| B | HOH301 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 203 |
| Chain | Residue |
| A | THR101 |
| A | ARG105 |
| B | ARG65 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue HRE B 201 |
| Chain | Residue |
| A | TYR100 |
| A | TYR104 |
| A | HOH335 |
| A | HOH351 |
| B | LEU54 |
| B | GLY58 |
| B | ILE61 |
| B | MET62 |
| B | TYR67 |
| B | GLN72 |
| B | PHE86 |
| B | VAL93 |
| B | HIS96 |
| B | ILE99 |
| B | TYR100 |
| B | HOH346 |
