3LBL

Structure of human MDM2 protein in complex with Mi-63-analog

Summary for 3LBL

Entry DOI	10.2210/pdb3lbl/pdb
Related	1YCR 3LBJ 3LBK
Descriptor	E3 ubiquitin-protein ligase Mdm2, (2'R,3R,4'R,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide (3 entities in total)
Functional Keywords	mdmx, mdm2, p53, inhibitor, alternative splicing, cytoplasm, ligase, nucleus, phosphoprotein, proto-oncogene, ubl conjugation, ubl conjugation pathway, zinc-finger
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	35161.91
Authors	Popowicz, G.M.,Czarna, A.,Wolf, S.,Holak, T.A. (deposition date: 2010-01-08, release date: 2010-03-16, Last modification date: 2023-11-01)
Primary citation	Popowicz, G.M.,Czarna, A.,Wolf, S.,Wang, K.,Wang, W.,Domling, A.,Holak, T.A. Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9:1104-1111, 2010 Cited by PubMed: 20237429 DOI: 10.4161/cc.9.6.10956 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation