3LBJ

Structure of human MDMX protein in complex with a small molecule inhibitor

Summary for 3LBJ

Entry DOI	10.2210/pdb3lbj/pdb
Related	3DAB 3LBK 3LBL
Descriptor	Protein Mdm4, N-[(3S)-1-({6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indol-2-yl}carbonyl)pyrrolidin-3-yl]-N,N',N'-trimethylpropane-1,3-diamine, SULFATE ION, ... (4 entities in total)
Functional Keywords	mdmx, mdm2, p53, inhibitor, alternative splicing, nucleus, polymorphism, zinc-finger, cell cycle
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	11647.40
Authors	Popowicz, G.M.,Czarna, A.,Wolf, S.,Holak, T.A. (deposition date: 2010-01-08, release date: 2010-03-16, Last modification date: 2023-11-01)
Primary citation	Popowicz, G.M.,Czarna, A.,Wolf, S.,Wang, K.,Wang, W.,Domling, A.,Holak, T.A. Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9:1104-1111, 2010 Cited by PubMed: 20237429 DOI: 10.4161/cc.9.6.10956 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation