3LBL
Structure of human MDM2 protein in complex with Mi-63-analog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, C, E) | E3 ubiquitin-protein ligase Mdm2 | polymer | 95 | 11143.1 | 3 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | p53-binding protein Mdm2, Oncoprotein Mdm2, Double minute 2 protein, Hdm2 |
| 2 | D, E, F (A, C, E) | (2'R,3R,4'R,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide | non-polymer | 577.5 | 3 | Chemie (MI6) | |||
| 3 | G, H, I (A, C, E) | water | water | 18.0 | 296 | Chemie (HOH) |
Sequence modifications
A, C, E: 18 - 111 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 33429.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 1732.6 | |
| All* | Total formula weight | 35161.9 |
