4UE1

Structure of the stapled peptide YS-01 bound to MDM2

Summary for 4UE1

• Entry DOI: 10.2210/pdb4ue1/pdb
• Related: 4UD7
• Descriptor: E3 UBIQUITIN-PROTEIN LIGASE MDM2, YS-01 (3 entities in total)
• Functional Keywords: ligase-peptide complex, ligase/peptide
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 8
• Total formula weight: 58619.08

Authors

Tan, Y.S.,Reeks, J.,Brown, C.J.,Jennings, C.E.,Eapen, R.S.,Tng, Q.S.,Thean, D.,Ying, Y.T.,Gago, F.J.F.,Lane, D.P.,Noble, M.E.M.,Verma, C. (deposition date: 2014-12-14, release date: 2016-01-13, Last modification date: 2023-12-20)

• Primary citation: Tan, Y.S.,Reeks, J.,Brown, C.J.,Thean, D.,Ferrer Gago, F.J.,Yuen, T.Y.,Goh, E.T.,Lee, X.E.,Jennings, C.E.,Joseph, T.L.,Lakshminarayanan, R.,Lane, D.P.,Noble, M.E.,Verma, C.S.; Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.; J Phys Chem Lett, 7:3452-3457, 2016; PubMed: 27532490; DOI: 10.1021/acs.jpclett.6b01525

Experimental method

X-RAY DIFFRACTION (1.45 Å)