4UE1
Structure of the stapled peptide YS-01 bound to MDM2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | E3 UBIQUITIN-PROTEIN LIGASE MDM2 | polymer | 114 | 12830.7 | 4 | UniProt (Q00987) Pfam (PF02201) | HOMO SAPIENS (HUMAN) | DOUBLE MINUTE 2 PROTEIN, HDM2, ONCOPROTEIN MDM2, P53-BINDING PROTEIN MDM2, MDM2 |
| 2 | E, F, G, H (F, G, H, I) | YS-01 | polymer | 16 | 1824.1 | 4 | HOMO SAPIENS | ||
| 3 | I, J, K, L, M... (A, B, C, D, F...) | water | water | 18.0 | 267 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 17 - 125 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| Pro 13 | - | expression tag |
| Leu 14 | - | expression tag |
| Gly 15 | - | expression tag |
| Ser 16 | - | expression tag |
| Ala 69 | Glu 69 | engineered mutation |
| Ala 70 | Lys 70 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 58619.1 | |
| All* | Total formula weight | 58619.1 |
