Summary for 4HBM
| Related | 4ERE 4ERF |
|---|---|
| Descriptor | E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-2-oxopiperidin-3-yl}acetic acid (3 entities in total) |
| Functional Keywords | mdm2, p53, protein protein interaction, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus, nucleoplasm Q00987 |
| Total number of polymer chains | 8 |
| Total molecular weight | 112367.06 |
| Authors | Huang, X. (deposition date: 2012-09-28, release date: 2012-10-17, Last modification date: 2013-01-02) |
| Primary citation | Michelsen, K.,Jordan, J.B.,Lewis, J.,Long, A.M.,Yang, E.,Rew, Y.,Zhou, J.,Yakowec, P.,Schnier, P.D.,Huang, X.,Poppe, L. Ordering of the N-terminus of human MDM2 by small molecule inhibitors. J.Am.Chem.Soc., 134:17059-17067, 2012 PubMed: 22991965 (PDB entries with the same primary citation) DOI: 10.1021/ja305839b  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
