Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors

Summary for 4HBM

Related4ERE 4ERF
DescriptorE3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-2-oxopiperidin-3-yl}acetic acid (3 entities in total)
Functional Keywordsmdm2, p53, protein protein interaction, inhibitor, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm Q00987
Total number of polymer chains8
Total molecular weight112367.06
Huang, X. (deposition date: 2012-09-28, release date: 2012-10-17, Last modification date: 2013-01-02)
Primary citation
Michelsen, K.,Jordan, J.B.,Lewis, J.,Long, A.M.,Yang, E.,Rew, Y.,Zhou, J.,Yakowec, P.,Schnier, P.D.,Huang, X.,Poppe, L.
Ordering of the N-terminus of human MDM2 by small molecule inhibitors.
J.Am.Chem.Soc., 134:17059-17067, 2012
PubMed: 22991965 (PDB entries with the same primary citation)
DOI: 10.1021/ja305839b
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24290.5%2.7%5.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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PDB entries from 2020-07-29