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4HBM

Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0043066biological_processnegative regulation of apoptotic process
A0051726biological_processregulation of cell cycle
B0005634cellular_componentnucleus
B0043066biological_processnegative regulation of apoptotic process
B0051726biological_processregulation of cell cycle
C0005634cellular_componentnucleus
C0043066biological_processnegative regulation of apoptotic process
C0051726biological_processregulation of cell cycle
D0005634cellular_componentnucleus
D0043066biological_processnegative regulation of apoptotic process
D0051726biological_processregulation of cell cycle
E0005634cellular_componentnucleus
E0043066biological_processnegative regulation of apoptotic process
E0051726biological_processregulation of cell cycle
F0005634cellular_componentnucleus
F0043066biological_processnegative regulation of apoptotic process
F0051726biological_processregulation of cell cycle
G0005634cellular_componentnucleus
G0043066biological_processnegative regulation of apoptotic process
G0051726biological_processregulation of cell cycle
H0005634cellular_componentnucleus
H0043066biological_processnegative regulation of apoptotic process
H0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 0Y7 A 201
ChainResidue
ATHR16
AHOH343
AHOH352
AHOH399
BGLN59
ALEU54
AGLY58
AILE61
AVAL93
ALYS94
AHIS96
ATYR100
AHOH305

site_idAC2
Number of Residues12
DetailsBINDING SITE FOR RESIDUE 0Y7 B 201
ChainResidue
BVAL14
BTHR16
BLEU54
BGLY58
BILE61
BVAL93
BLYS94
BHIS96
BTYR100
BHOH309
BHOH332
BHOH368

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 0Y7 C 201
ChainResidue
CVAL14
CTHR16
CLEU54
CGLY58
CILE61
CVAL93
CLYS94
CHIS96
CHOH310
EGLN59
EHOH306
EHOH315
EHOH375

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 0Y7 D 201
ChainResidue
DVAL14
DTHR16
DLEU54
DGLY58
DILE61
DMET62
DVAL93
DLYS94
DHIS96
DHOH302
DHOH344
DHOH394
FGLN59
FHOH348

site_idAC5
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 0Y7 E 201
ChainResidue
CGLN59
CHOH349
EVAL14
ETHR16
ELEU54
EGLY58
EILE61
EVAL93
ELYS94
EHIS96
ETYR100
EHOH303
EHOH347

site_idAC6
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 0Y7 F 201
ChainResidue
DGLN59
DHOH324
DHOH325
FVAL14
FLEU54
FGLY58
FILE61
FVAL93
FLYS94
FHIS96
FTYR100
FHOH303
FHOH327
FHOH395

site_idAC7
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 0Y7 G 201
ChainResidue
GTHR16
GLEU54
GGLY58
GILE61
GMET62
GVAL93
GLYS94
GHIS96
GILE99
GHOH302
GHOH342
HHOH324
HHOH352

site_idAC8
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 0Y7 H 201
ChainResidue
HILE61
HMET62
HVAL93
HLYS94
HHIS96
HHOH303
GGLN59
GHOH339
GHOH361
HVAL14
HTHR16
HLEU54
HGLY58

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PDB entries from 2024-04-17

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