4HBM
Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005634 | cellular_component | nucleus |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0051726 | biological_process | regulation of cell cycle |
B | 0005634 | cellular_component | nucleus |
B | 0043066 | biological_process | negative regulation of apoptotic process |
B | 0051726 | biological_process | regulation of cell cycle |
C | 0005634 | cellular_component | nucleus |
C | 0043066 | biological_process | negative regulation of apoptotic process |
C | 0051726 | biological_process | regulation of cell cycle |
D | 0005634 | cellular_component | nucleus |
D | 0043066 | biological_process | negative regulation of apoptotic process |
D | 0051726 | biological_process | regulation of cell cycle |
E | 0005634 | cellular_component | nucleus |
E | 0043066 | biological_process | negative regulation of apoptotic process |
E | 0051726 | biological_process | regulation of cell cycle |
F | 0005634 | cellular_component | nucleus |
F | 0043066 | biological_process | negative regulation of apoptotic process |
F | 0051726 | biological_process | regulation of cell cycle |
G | 0005634 | cellular_component | nucleus |
G | 0043066 | biological_process | negative regulation of apoptotic process |
G | 0051726 | biological_process | regulation of cell cycle |
H | 0005634 | cellular_component | nucleus |
H | 0043066 | biological_process | negative regulation of apoptotic process |
H | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 0Y7 A 201 |
Chain | Residue |
A | THR16 |
A | HOH343 |
A | HOH352 |
A | HOH399 |
B | GLN59 |
A | LEU54 |
A | GLY58 |
A | ILE61 |
A | VAL93 |
A | LYS94 |
A | HIS96 |
A | TYR100 |
A | HOH305 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 0Y7 B 201 |
Chain | Residue |
B | VAL14 |
B | THR16 |
B | LEU54 |
B | GLY58 |
B | ILE61 |
B | VAL93 |
B | LYS94 |
B | HIS96 |
B | TYR100 |
B | HOH309 |
B | HOH332 |
B | HOH368 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 0Y7 C 201 |
Chain | Residue |
C | VAL14 |
C | THR16 |
C | LEU54 |
C | GLY58 |
C | ILE61 |
C | VAL93 |
C | LYS94 |
C | HIS96 |
C | HOH310 |
E | GLN59 |
E | HOH306 |
E | HOH315 |
E | HOH375 |
site_id | AC4 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 0Y7 D 201 |
Chain | Residue |
D | VAL14 |
D | THR16 |
D | LEU54 |
D | GLY58 |
D | ILE61 |
D | MET62 |
D | VAL93 |
D | LYS94 |
D | HIS96 |
D | HOH302 |
D | HOH344 |
D | HOH394 |
F | GLN59 |
F | HOH348 |
site_id | AC5 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 0Y7 E 201 |
Chain | Residue |
C | GLN59 |
C | HOH349 |
E | VAL14 |
E | THR16 |
E | LEU54 |
E | GLY58 |
E | ILE61 |
E | VAL93 |
E | LYS94 |
E | HIS96 |
E | TYR100 |
E | HOH303 |
E | HOH347 |
site_id | AC6 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 0Y7 F 201 |
Chain | Residue |
D | GLN59 |
D | HOH324 |
D | HOH325 |
F | VAL14 |
F | LEU54 |
F | GLY58 |
F | ILE61 |
F | VAL93 |
F | LYS94 |
F | HIS96 |
F | TYR100 |
F | HOH303 |
F | HOH327 |
F | HOH395 |
site_id | AC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 0Y7 G 201 |
Chain | Residue |
G | THR16 |
G | LEU54 |
G | GLY58 |
G | ILE61 |
G | MET62 |
G | VAL93 |
G | LYS94 |
G | HIS96 |
G | ILE99 |
G | HOH302 |
G | HOH342 |
H | HOH324 |
H | HOH352 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 0Y7 H 201 |
Chain | Residue |
H | ILE61 |
H | MET62 |
H | VAL93 |
H | LYS94 |
H | HIS96 |
H | HOH303 |
G | GLN59 |
G | HOH339 |
G | HOH361 |
H | VAL14 |
H | THR16 |
H | LEU54 |
H | GLY58 |