4HBM
Ordering of the N Terminus of Human MDM2 by Small Molecule Inhibitors
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
| C | 0005634 | cellular_component | nucleus |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0051726 | biological_process | regulation of cell cycle |
| D | 0005634 | cellular_component | nucleus |
| D | 0043066 | biological_process | negative regulation of apoptotic process |
| D | 0051726 | biological_process | regulation of cell cycle |
| E | 0005634 | cellular_component | nucleus |
| E | 0043066 | biological_process | negative regulation of apoptotic process |
| E | 0051726 | biological_process | regulation of cell cycle |
| F | 0005634 | cellular_component | nucleus |
| F | 0043066 | biological_process | negative regulation of apoptotic process |
| F | 0051726 | biological_process | regulation of cell cycle |
| G | 0005634 | cellular_component | nucleus |
| G | 0043066 | biological_process | negative regulation of apoptotic process |
| G | 0051726 | biological_process | regulation of cell cycle |
| H | 0005634 | cellular_component | nucleus |
| H | 0043066 | biological_process | negative regulation of apoptotic process |
| H | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 0Y7 A 201 |
| Chain | Residue |
| A | THR16 |
| A | HOH343 |
| A | HOH352 |
| A | HOH399 |
| B | GLN59 |
| A | LEU54 |
| A | GLY58 |
| A | ILE61 |
| A | VAL93 |
| A | LYS94 |
| A | HIS96 |
| A | TYR100 |
| A | HOH305 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE 0Y7 B 201 |
| Chain | Residue |
| B | VAL14 |
| B | THR16 |
| B | LEU54 |
| B | GLY58 |
| B | ILE61 |
| B | VAL93 |
| B | LYS94 |
| B | HIS96 |
| B | TYR100 |
| B | HOH309 |
| B | HOH332 |
| B | HOH368 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 0Y7 C 201 |
| Chain | Residue |
| C | VAL14 |
| C | THR16 |
| C | LEU54 |
| C | GLY58 |
| C | ILE61 |
| C | VAL93 |
| C | LYS94 |
| C | HIS96 |
| C | HOH310 |
| E | GLN59 |
| E | HOH306 |
| E | HOH315 |
| E | HOH375 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 0Y7 D 201 |
| Chain | Residue |
| D | VAL14 |
| D | THR16 |
| D | LEU54 |
| D | GLY58 |
| D | ILE61 |
| D | MET62 |
| D | VAL93 |
| D | LYS94 |
| D | HIS96 |
| D | HOH302 |
| D | HOH344 |
| D | HOH394 |
| F | GLN59 |
| F | HOH348 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 0Y7 E 201 |
| Chain | Residue |
| C | GLN59 |
| C | HOH349 |
| E | VAL14 |
| E | THR16 |
| E | LEU54 |
| E | GLY58 |
| E | ILE61 |
| E | VAL93 |
| E | LYS94 |
| E | HIS96 |
| E | TYR100 |
| E | HOH303 |
| E | HOH347 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE 0Y7 F 201 |
| Chain | Residue |
| D | GLN59 |
| D | HOH324 |
| D | HOH325 |
| F | VAL14 |
| F | LEU54 |
| F | GLY58 |
| F | ILE61 |
| F | VAL93 |
| F | LYS94 |
| F | HIS96 |
| F | TYR100 |
| F | HOH303 |
| F | HOH327 |
| F | HOH395 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 0Y7 G 201 |
| Chain | Residue |
| G | THR16 |
| G | LEU54 |
| G | GLY58 |
| G | ILE61 |
| G | MET62 |
| G | VAL93 |
| G | LYS94 |
| G | HIS96 |
| G | ILE99 |
| G | HOH302 |
| G | HOH342 |
| H | HOH324 |
| H | HOH352 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 0Y7 H 201 |
| Chain | Residue |
| H | ILE61 |
| H | MET62 |
| H | VAL93 |
| H | LYS94 |
| H | HIS96 |
| H | HOH303 |
| G | GLN59 |
| G | HOH339 |
| G | HOH361 |
| H | VAL14 |
| H | THR16 |
| H | LEU54 |
| H | GLY58 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 249 |
| Details | Domain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |






