3JZS

Human MDM2 liganded with a 12mer peptide inhibitor (pDIQ)

Summary for 3JZS

Related3JZR 3JZO 3JZP 3JZQ
DescriptorE3 ubiquitin-protein ligase Mdm2, pDIQ peptide (12mer), 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywordsp53-binding protein mdm2, oncoprotein mdm2, double minute 2 protein, hdm2, alternative splicing, cytoplasm, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm Q00987
Total number of polymer chains2
Total molecular weight11798.77
Authors
Schonbrunn, E.,Phan, J. (deposition date: 2009-09-24, release date: 2009-11-10, Last modification date: 2011-07-13)
Primary citation
Phan, J.,Li, Z.,Kasprzak, A.,Li, B.,Sebti, S.,Guida, W.,Schonbrunn, E.,Chen, J.
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285:2174-2183, 2010
PubMed: 19910468 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M109.073056
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.78 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2471001.1%6.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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