3JZS

Human MDM2 liganded with a 12mer peptide inhibitor (pDIQ)

Summary for 3JZS

Entry DOI	10.2210/pdb3jzs/pdb
Related	3JZO 3JZP 3JZQ 3JZR
Descriptor	E3 ubiquitin-protein ligase Mdm2, pDIQ peptide (12mer), 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	p53-binding protein mdm2, oncoprotein mdm2, double minute 2 protein, hdm2, alternative splicing, cytoplasm, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger
Biological source	Homo sapiens (human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	2
Total formula weight	11798.77
Authors	Schonbrunn, E.,Phan, J. (deposition date: 2009-09-24, release date: 2009-11-10, Last modification date: 2023-09-06)
Primary citation	Phan, J.,Li, Z.,Kasprzak, A.,Li, B.,Sebti, S.,Guida, W.,Schonbrunn, E.,Chen, J. Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285:2174-2183, 2010 Cited by PubMed: 19910468 DOI: 10.1074/jbc.M109.073056 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation