3JZR
Human MDM2 liganded with a 12mer peptide inhibitor (pDI6W)
Summary for 3JZR
| Entry DOI | 10.2210/pdb3jzr/pdb |
| Related | 3JZO 3JZP 3JZQ 3JZS |
| Descriptor | E3 ubiquitin-protein ligase Mdm2, pDI6W peptide (12mer) (3 entities in total) |
| Functional Keywords | p53-binding protein mdm2, oncoprotein mdm2, double minute 2 protein, hdm2, alternative splicing, cytoplasm, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation, ubl conjugation pathway, zinc, zinc-finger |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus, nucleoplasm: Q00987 |
| Total number of polymer chains | 2 |
| Total formula weight | 14112.08 |
| Authors | Schonbrunn, E.,Phan, J. (deposition date: 2009-09-24, release date: 2009-11-10, Last modification date: 2023-09-06) |
| Primary citation | Phan, J.,Li, Z.,Kasprzak, A.,Li, B.,Sebti, S.,Guida, W.,Schonbrunn, E.,Chen, J. Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285:2174-2183, 2010 Cited by PubMed: 19910468DOI: 10.1074/jbc.M109.073056 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
Download full validation report
