3JZQ

Human MDMX liganded with a 12mer peptide inhibitor (pDIQ)

Summary for 3JZQ

Related3JZO 3JZP 3JZR 3JZS
DescriptorProtein Mdm4, pDIQ peptide (12mer), SULFATE ION, ... (4 entities in total)
Functional Keywordscell cycle, p53-binding protein mdm4, double minute 4 protein, alternative splicing, metal-binding, nucleus, polymorphism, zinc, zinc-finger
Biological sourceHomo sapiens (human)
Cellular locationNucleus O15151
Total number of polymer chains4
Total molecular weight23545.23
Authors
Schonbrunn, E.,Phan, J. (deposition date: 2009-09-24, release date: 2009-11-10, Last modification date: 2011-07-13)
Primary citation
Phan, J.,Li, Z.,Kasprzak, A.,Li, B.,Sebti, S.,Guida, W.,Schonbrunn, E.,Chen, J.
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
J.Biol.Chem., 285:2174-2183, 2010
PubMed: 19910468 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M109.073056
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.224600.6%3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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More Biological unit images

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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3jzq.pdb1.gz [18.78 KB])
Coordinate files for Biological unit (3jzq.pdb2.gz [19.17 KB])