6Q9O

HDM2 (17-111, WILDTYPE) COMPLEXED WITH COMPOUND 10 AT 1.21A; Structural states of Hdm2 and HdmX: X-ray elucidation of adaptations and binding interactions for different chemical compound classes

Summary for 6Q9O

• Entry DOI: 10.2210/pdb6q9o/pdb
• Related: 4OQ3
• Descriptor: E3 ubiquitin-protein ligase Mdm2, ~{N}-~{tert}-butyl-2-[4-chloranyl-2-[5-(3-chloranyl-4-fluoranyl-phenyl)-2-cyclohexyl-4-(1~{H}-1,2,3,4-tetrazol-5-yl)imidazol-1-yl]phenyl]ethanamide (3 entities in total)
• Functional Keywords: ppi with p53, inhibitor complex, cell cycle, ligase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 23453.08

Authors

Kallen, J. (deposition date: 2018-12-18, release date: 2019-05-15, Last modification date: 2024-01-24)

• Primary citation: Kallen, J.,Izaac, A.,Chau, S.,Wirth, E.,Schoepfer, J.,Mah, R.,Schlapbach, A.,Stutz, S.,Vaupel, A.,Guagnano, V.,Masuya, K.,Stachyra, T.M.,Salem, B.,Chene, P.,Gessier, F.,Holzer, P.,Furet, P.; Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.; Chemmedchem, 14:1305-1314, 2019; PubMed: 31066983; DOI: 10.1002/cmdc.201900201

Experimental method

X-RAY DIFFRACTION (1.21 Å)