7BII
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![BU of 7bii by Molmil](/molmil-images/mine/7bii) | Crystal structure of Nematocida HUWE1 | Descriptor: | E3 ubiquitin-protein ligase HUWE1 | Authors: | Grabarczyk, D.B, Petrova, O.A, Meinhart, A, Kessler, D, Clausen, T. | Deposit date: | 2021-01-12 | Release date: | 2021-07-28 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.037 Å) | Cite: | HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain. Nat.Chem.Biol., 17, 2021
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8BJA
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![BU of 8bja by Molmil](/molmil-images/mine/8bja) | |
8C06
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![BU of 8c06 by Molmil](/molmil-images/mine/8c06) | |
8D4X
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![BU of 8d4x by Molmil](/molmil-images/mine/8d4x) | Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a dimeric form | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Wang, F, He, Q, Lin, G, Li, H. | Deposit date: | 2022-06-02 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structure of the human UBR5 E3 ubiquitin ligase. Structure, 31, 2023
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8E0Q
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![BU of 8e0q by Molmil](/molmil-images/mine/8e0q) | Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a C2 symmetric dimeric form | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Wang, F, He, Q, Lin, G, Li, H. | Deposit date: | 2022-08-09 | Release date: | 2023-04-19 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Structure of the human UBR5 E3 ubiquitin ligase. Structure, 31, 2023
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8EWI
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![BU of 8ewi by Molmil](/molmil-images/mine/8ewi) | Structure of the human UBR5 HECT-type E3 ubiquitin ligase in a tetrameric form | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Wang, F, He, Q, Lin, G, Li, H. | Deposit date: | 2022-10-23 | Release date: | 2023-04-19 | Last modified: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the human UBR5 E3 ubiquitin ligase. Structure, 31, 2023
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8P82
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![BU of 8p82 by Molmil](/molmil-images/mine/8p82) | Cryo-EM structure of dimeric UBR5 | Descriptor: | E3 ubiquitin-protein ligase UBR5, ZINC ION | Authors: | Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2023-05-31 | Release date: | 2023-06-14 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability To Be Published
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8P83
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![BU of 8p83 by Molmil](/molmil-images/mine/8p83) | Cryo-EM structure of full-length human UBR5 (homotetramer) | Descriptor: | E3 ubiquitin-protein ligase UBR5 | Authors: | Aguirre, J.D, Kater, L, Kempf, G, Cavadini, S, Thoma, N.H. | Deposit date: | 2023-05-31 | Release date: | 2023-06-14 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (3.87 Å) | Cite: | UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Mol.Cell, 83, 2023
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7NH3
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![BU of 7nh3 by Molmil](/molmil-images/mine/7nh3) | Nematocida Huwe1 in open conformation. | Descriptor: | E3 ubiquitin-protein ligase HUWE1 | Authors: | Petrova, O, Grishkovskaya, I, Grabarczyk, D.B, Kessler, D, Haselbach, D, Clausen, T. | Deposit date: | 2021-02-09 | Release date: | 2022-03-02 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (6.37 Å) | Cite: | Crystal structure of HUWE1: One ring to ubiquitinate them all To Be Published
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8PWL
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![BU of 8pwl by Molmil](/molmil-images/mine/8pwl) | |
8H8X
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![BU of 8h8x by Molmil](/molmil-images/mine/8h8x) | Cryo-EM structure of HACE1 monomer | Descriptor: | E3 ubiquitin-protein ligase HACE1 | Authors: | Singh, S, Machida, S, Tulsian, N.K, Choong, Y.K, Ng, J, Shanker, S, Yaochen, L.D, Shi, J, Sivaraman, J. | Deposit date: | 2022-10-24 | Release date: | 2023-06-28 | Last modified: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (3.92 Å) | Cite: | Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization. Adv Sci, 10, 2023
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8HAE
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![BU of 8hae by Molmil](/molmil-images/mine/8hae) | Cryo-EM structure of HACE1 dimer | Descriptor: | E3 ubiquitin-protein ligase HACE1 | Authors: | Singh, S, Machida, S, Tulsian, N.K, Choong, Y.K, Ng, J, Shanker, S, Yaochen, L.D, Shi, J, Sivaraman, J, Machida, S. | Deposit date: | 2022-10-26 | Release date: | 2023-06-28 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (4.55 Å) | Cite: | Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization. Adv Sci, 10, 2023
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5XMC
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![BU of 5xmc by Molmil](/molmil-images/mine/5xmc) | |
6XZ1
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![BU of 6xz1 by Molmil](/molmil-images/mine/6xz1) | Conjugate of the HECT domain of HUWE1 with ubiquitin | Descriptor: | HECT, UBA and WWE domain containing 1, isoform CRA_a, ... | Authors: | Liu, B, Seenivasan, A, Nair, R, Chen, D, Lowe, E.D, Lorenz, S. | Deposit date: | 2020-01-31 | Release date: | 2021-08-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe. Acs Chem.Biol., 16, 2021
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4LCD
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![BU of 4lcd by Molmil](/molmil-images/mine/4lcd) | |
7JQ9
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![BU of 7jq9 by Molmil](/molmil-images/mine/7jq9) | Cryo-EM structure of human HUWE1 | Descriptor: | E3 ubiquitin-protein ligase HUWE1 | Authors: | Hunkeler, M, Fischer, E.S. | Deposit date: | 2020-08-10 | Release date: | 2021-07-28 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Mol.Cell, 81, 2021
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3OLM
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![BU of 3olm by Molmil](/molmil-images/mine/3olm) | Structure and Function of a Ubiquitin Binding Site within the Catalytic Domain of a HECT Ubiquitin Ligase | Descriptor: | E3 ubiquitin-protein ligase RSP5, Ubiquitin | Authors: | Kim, H.C, Steffen, A, Chen, J, Huibregtse, J.M. | Deposit date: | 2010-08-26 | Release date: | 2011-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.495 Å) | Cite: | Structure and function of a HECT domain ubiquitin-binding site. Embo Rep., 12, 2011
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8R1G
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![BU of 8r1g by Molmil](/molmil-images/mine/8r1g) | Dimeric ternary structure of E6AP-E6-p53 | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakrabory, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | Monomeric E6AP-E6-p53 ternary complex To Be Published
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8R1F
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![BU of 8r1f by Molmil](/molmil-images/mine/8r1f) | Monomeric E6AP-E6-p53 ternary complex | Descriptor: | Cellular tumor antigen p53, Ubiquitin-like protein SMT3,Protein E6, Ubiquitin-protein ligase E3A, ... | Authors: | Sandate, C.R, Chakraborty, D, Kater, L, Kempf, G, Thoma, N.H. | Deposit date: | 2023-11-01 | Release date: | 2023-12-06 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Monomeric E6AP-E6-p53 ternary complex To Be Published
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1C4Z
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![BU of 1c4z by Molmil](/molmil-images/mine/1c4z) | STRUCTURE OF AN E6AP-UBCH7 COMPLEX: INSIGHTS INTO THE UBIQUITINATION PATHWAY | Descriptor: | UBIQUITIN CONJUGATING ENZYME E2, UBIQUITIN-PROTEIN LIGASE E3A | Authors: | Huang, L, Kinnucan, E, Wang, G, Beaudenon, S, Howley, P.M, Huibregtse, J.M, Pavletich, N.P. | Deposit date: | 1999-10-14 | Release date: | 1999-11-17 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade. Science, 286, 1999
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8C07
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![BU of 8c07 by Molmil](/molmil-images/mine/8c07) | |
6FYH
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![BU of 6fyh by Molmil](/molmil-images/mine/6fyh) | Disulfide between ubiquitin G76C and the E3 HECT ligase Huwe1 | Descriptor: | E3 ubiquitin-protein ligase HUWE1, Polyubiquitin-B, SULFATE ION, ... | Authors: | Jaeckl, M, Hartmann, M.D, Wiesner, S. | Deposit date: | 2018-03-12 | Release date: | 2018-07-11 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.906 Å) | Cite: | beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation. J. Mol. Biol., 430, 2018
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6FX4
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![BU of 6fx4 by Molmil](/molmil-images/mine/6fx4) | |
2XBB
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![BU of 2xbb by Molmil](/molmil-images/mine/2xbb) | Nedd4 HECT:Ub complex | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE NEDD4, GLYCEROL, UBIQUITIN | Authors: | Maspero, E, Cecatiello, V, Musacchio, A, Polo, S, Pasqualato, S. | Deposit date: | 2010-04-08 | Release date: | 2011-03-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Structure of the Hect:Ubiquitin Complex and its Role in Ubiquitin Chain Elongation Embo Rep., 12, 2011
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4BBN
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![BU of 4bbn by Molmil](/molmil-images/mine/4bbn) | NEDD4 HECT-Ub:Ub complex | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE NEDD4, POLYUBIQUITIN-B | Authors: | Maspero, E, Valentini, E, Mari, S, Cecatiello, V, Polo, S, Pasqualato, S. | Deposit date: | 2012-09-27 | Release date: | 2013-05-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming Nat.Struct.Mol.Biol., 20, 2013
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