6XZ1

Conjugate of the HECT domain of HUWE1 with ubiquitin

Summary for 6XZ1

Entry DOI	10.2210/pdb6xz1/pdb
Descriptor	HECT, UBA and WWE domain containing 1, isoform CRA_a, Polyubiquitin-B, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	ubiquitin ligase, e3 enzyme, ubiquitin-propargylamide, activity-based probe, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	107826.82
Authors	Liu, B.,Seenivasan, A.,Nair, R.,Chen, D.,Lowe, E.D.,Lorenz, S. (deposition date: 2020-01-31, release date: 2021-08-25, Last modification date: 2024-01-24)
Primary citation	Nair, R.M.,Seenivasan, A.,Liu, B.,Chen, D.,Lowe, E.D.,Lorenz, S. Reconstitution and Structural Analysis of a HECT Ligase-Ubiquitin Complex via an Activity-Based Probe. Acs Chem.Biol., 16:1615-1621, 2021 Cited by PubMed: 34403242 DOI: 10.1021/acschembio.1c00433 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation