7BII

Crystal structure of Nematocida HUWE1

Summary for 7BII

Entry DOI	10.2210/pdb7bii/pdb
Descriptor	E3 ubiquitin-protein ligase HUWE1 (1 entity in total)
Functional Keywords	hect e3 ligase, ubiquitin, protein quality control, ligase
Biological source	Nematocida sp. ERTm5
Total number of polymer chains	2
Total formula weight	575746.75
Authors	Grabarczyk, D.B.,Petrova, O.A.,Meinhart, A.,Kessler, D.,Clausen, T. (deposition date: 2021-01-12, release date: 2021-07-28, Last modification date: 2024-01-31)
Primary citation	Grabarczyk, D.B.,Petrova, O.A.,Deszcz, L.,Kurzbauer, R.,Murphy, P.,Ahel, J.,Vogel, A.,Gogova, R.,Faas, V.,Kordic, D.,Schleiffer, A.,Meinhart, A.,Imre, R.,Lehner, A.,Neuhold, J.,Bader, G.,Stolt-Bergner, P.,Bottcher, J.,Wolkerstorfer, B.,Fischer, G.,Grishkovskaya, I.,Haselbach, D.,Kessler, D.,Clausen, T. HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain. Nat.Chem.Biol., 17:1084-1092, 2021 Cited by PubMed: 34294896 DOI: 10.1038/s41589-021-00831-5 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.037 Å)

Structure validation