6FX4

Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C

Summary for 6FX4

Entry DOI	10.2210/pdb6fx4/pdb
Descriptor	E3 ubiquitin-protein ligase SMURF2, Polyubiquitin-B, GLYCEROL, ... (4 entities in total)
Functional Keywords	e3 hect ligase, ubiquitin transfer, ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	45319.67
Authors	Jaeckl, M.,Holdermann, I.,Wiesner, S. (deposition date: 2018-03-08, release date: 2018-07-11, Last modification date: 2024-01-17)
Primary citation	Jackl, M.,Stollmaier, C.,Strohaker, T.,Hyz, K.,Maspero, E.,Polo, S.,Wiesner, S. beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation. J. Mol. Biol., 430:3218-3233, 2018 Cited by PubMed: 29964046 DOI: 10.1016/j.jmb.2018.06.044 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation