6FX4
Disulfide between E3 HECT ligase Smurf2 and Ubiquitin G76C
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | E3 ubiquitin-protein ligase SMURF2 | polymer | 122 | 13944.8 | 2 | UniProt (Q9HAU4) Pfam (PF00632) In PDB | Homo sapiens (Human) | hSMURF2,HECT-type E3 ubiquitin transferase SMURF2,SMAD ubiquitination regulatory factor 2,SMAD-specific E3 ubiquitin-protein ligase 2 |
2 | B, D | Polyubiquitin-B | polymer | 76 | 8622.9 | 2 | UniProt (P0CG47) Pfam (PF00240) In PDB | Homo sapiens (Human) | |
3 | A, C | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
4 | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 115 (UniProt: Q9HAU4)
B, D: 1 - 76 (UniProt: P0CG47)
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Ala -2 | - | expression tag |
Met -1 | - | expression tag |
Gly 0 | - | expression tag |
Ala 16 | Cys 646 | engineered mutation |
Asn 76 | Cys 706 | engineered mutation |
Ser 113 | Cys 743 | engineered mutation |
Ala 116 | - | expression tag |
Val 117 | - | expression tag |
Glu 118 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Cys 76 | Gly 76 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 45135.5 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 184.2 | |
All* | Total formula weight | 45319.7 |