8H8X

Cryo-EM structure of HACE1 monomer

Summary for 8H8X

Entry DOI	10.2210/pdb8h8x/pdb
EMDB information	34551
Descriptor	E3 ubiquitin-protein ligase HACE1 (1 entity in total)
Functional Keywords	e3 ubiquitin ligase, tumor suppressor, post-translational modifier, protein degradation, antitumor protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	102449.67
Authors	Singh, S.,Machida, S.,Tulsian, N.K.,Choong, Y.K.,Ng, J.,Shanker, S.,Yaochen, L.D.,Shi, J.,Sivaraman, J. (deposition date: 2022-10-24, release date: 2023-06-28, Last modification date: 2024-01-10)
Primary citation	Singh, S.,Machida, S.,Tulsian, N.K.,Choong, Y.K.,Ng, J.,Shankar, S.,Liu, Y.,Chandiramani, K.V.,Shi, J.,Sivaraman, J. Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization. Adv Sci, 10:e2207672-e2207672, 2023 Cited by PubMed: 37537642 DOI: 10.1002/advs.202207672 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.92 Å)

Structure validation