8HAE
Cryo-EM structure of HACE1 dimer
Summary for 8HAE
Entry DOI | 10.2210/pdb8hae/pdb |
EMDB information | 34586 |
Descriptor | E3 ubiquitin-protein ligase HACE1 (1 entity in total) |
Functional Keywords | e3 ubiquitin ligase, tumor suppressor, post-translational modifier, protein degradation, antitumor protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 204899.34 |
Authors | Singh, S.,Machida, S.,Tulsian, N.K.,Choong, Y.K.,Ng, J.,Shanker, S.,Yaochen, L.D.,Shi, J.,Sivaraman, J.,Machida, S. (deposition date: 2022-10-26, release date: 2023-06-28, Last modification date: 2023-10-04) |
Primary citation | Singh, S.,Machida, S.,Tulsian, N.K.,Choong, Y.K.,Ng, J.,Shankar, S.,Liu, Y.,Chandiramani, K.V.,Shi, J.,Sivaraman, J. Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization. Adv Sci, 10:e2207672-e2207672, 2023 Cited by PubMed: 37537642DOI: 10.1002/advs.202207672 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.55 Å) |
Structure validation
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