8HAE

Cryo-EM structure of HACE1 dimer

Summary for 8HAE

• Entry DOI: 10.2210/pdb8hae/pdb
• EMDB information: 34586
• Descriptor: E3 ubiquitin-protein ligase HACE1 (1 entity in total)
• Functional Keywords: e3 ubiquitin ligase, tumor suppressor, post-translational modifier, protein degradation, antitumor protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 204899.34

Authors

Singh, S.,Machida, S.,Tulsian, N.K.,Choong, Y.K.,Ng, J.,Shanker, S.,Yaochen, L.D.,Shi, J.,Sivaraman, J.,Machida, S. (deposition date: 2022-10-26, release date: 2023-06-28, Last modification date: 2023-10-04)

• Primary citation: Singh, S.,Machida, S.,Tulsian, N.K.,Choong, Y.K.,Ng, J.,Shankar, S.,Liu, Y.,Chandiramani, K.V.,Shi, J.,Sivaraman, J.; Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization.; Adv Sci, 10:e2207672-e2207672, 2023; PubMed: 37537642; DOI: 10.1002/advs.202207672

Experimental method

ELECTRON MICROSCOPY (4.55 Å)