8HAE
Cryo-EM structure of HACE1 dimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000139 | cellular_component | Golgi membrane |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0007030 | biological_process | Golgi organization |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016601 | biological_process | Rac protein signal transduction |
| A | 0016740 | molecular_function | transferase activity |
| A | 0030334 | biological_process | regulation of cell migration |
| A | 0031267 | molecular_function | small GTPase binding |
| A | 0032580 | cellular_component | Golgi cisterna membrane |
| A | 0061025 | biological_process | membrane fusion |
| A | 0061630 | molecular_function | ubiquitin protein ligase activity |
| A | 0070936 | biological_process | protein K48-linked ubiquitination |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| B | 0007030 | biological_process | Golgi organization |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0016601 | biological_process | Rac protein signal transduction |
| B | 0016740 | molecular_function | transferase activity |
| B | 0030334 | biological_process | regulation of cell migration |
| B | 0031267 | molecular_function | small GTPase binding |
| B | 0032580 | cellular_component | Golgi cisterna membrane |
| B | 0061025 | biological_process | membrane fusion |
| B | 0061630 | molecular_function | ubiquitin protein ligase activity |
| B | 0070936 | biological_process | protein K48-linked ubiquitination |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 64 |
| Details | Repeat: {"description":"ANK 1","evidences":[{"source":"PubMed","id":"37537642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8H8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8PWL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"37537642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8H8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8PWL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"37537642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8H8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8PWL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"37537642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8H8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8PWL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 58 |
| Details | Repeat: {"description":"ANK 5","evidences":[{"source":"PubMed","id":"37537642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8H8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8PWL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 60 |
| Details | Repeat: {"description":"ANK 6","evidences":[{"source":"PubMed","id":"37537642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8H8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8PWL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 50 |
| Details | Repeat: {"description":"ANK 7","evidences":[{"source":"PubMed","id":"37537642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8H8X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8HAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8PWL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | Region: {"description":"N-terminal helix important for homodimerization","evidences":[{"source":"PubMed","id":"37537642","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38332367","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Glycyl thioester intermediate"} |
| Chain | Residue | Details |
