8P83

Cryo-EM structure of full-length human UBR5 (homotetramer)

Summary for 8P83

Entry DOI	10.2210/pdb8p83/pdb
EMDB information	17540
Descriptor	E3 ubiquitin-protein ligase UBR5 (1 entity in total)
Functional Keywords	e3, ubiquitin ligase, hect, ligase
Biological source	Homo sapiens (human)
Total number of polymer chains	4
Total formula weight	1253054.75
Authors	Aguirre, J.D.,Kater, L.,Kempf, G.,Cavadini, S.,Thoma, N.H. (deposition date: 2023-05-31, release date: 2023-06-14, Last modification date: 2023-08-16)
Primary citation	Tsai, J.M.,Aguirre, J.D.,Li, Y.D.,Brown, J.,Focht, V.,Kater, L.,Kempf, G.,Sandoval, B.,Schmitt, S.,Rutter, J.C.,Galli, P.,Sandate, C.R.,Cutler, J.A.,Zou, C.,Donovan, K.A.,Lumpkin, R.J.,Cavadini, S.,Park, P.M.C.,Sievers, Q.,Hatton, C.,Ener, E.,Regalado, B.D.,Sperling, M.T.,Slabicki, M.,Kim, J.,Zon, R.,Zhang, Z.,Miller, P.G.,Belizaire, R.,Sperling, A.S.,Fischer, E.S.,Irizarry, R.,Armstrong, S.A.,Thoma, N.H.,Ebert, B.L. UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. Mol.Cell, 83:2753-, 2023 Cited by PubMed: 37478846 DOI: 10.1016/j.molcel.2023.06.028 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.87 Å)

Structure validation