8PWL

Cryo-EM structure of a full-length HACE1 dimer

Summary for 8PWL

Entry DOI	10.2210/pdb8pwl/pdb
EMDB information	17994
Descriptor	E3 ubiquitin-protein ligase HACE1 (1 entity in total)
Functional Keywords	e3, hect, ubiquitin, ligase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	205013.44
Authors	Duering, J.,Wolter, M.,Dienemann, C.,Lorenz, S. (deposition date: 2023-07-20, release date: 2024-01-10, Last modification date: 2024-02-28)
Primary citation	During, J.,Wolter, M.,Toplak, J.J.,Torres, C.,Dybkov, O.,Fokkens, T.J.,Bohnsack, K.E.,Urlaub, H.,Steinchen, W.,Dienemann, C.,Lorenz, S. Structural mechanisms of autoinhibition and substrate recognition by the ubiquitin ligase HACE1. Nat.Struct.Mol.Biol., 31:364-377, 2024 Cited by PubMed: 38332367 DOI: 10.1038/s41594-023-01203-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.73 Å)

Structure validation