8C07

Structure of HECT E3 UBR5 forming K48 linked Ubiquitin chains

Summary for 8C07

Entry DOI	10.2210/pdb8c07/pdb
EMDB information	16356
Descriptor	E3 ubiquitin-protein ligase UBR5, Polyubiquitin-B, 5-azanylpentan-2-one, ... (4 entities in total)
Functional Keywords	e3 ligase, ubr5, ubiquitination, ubq, ubiquitin, hect, k48, ubq-chain, polyubiquitylation, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	637761.15
Authors	Hehl, L.A.,Prabu, J.R.,Schulman, B.A. (deposition date: 2022-12-16, release date: 2023-08-23, Last modification date: 2024-02-14)
Primary citation	Hehl, L.A.,Horn-Ghetko, D.,Prabu, J.R.,Vollrath, R.,Vu, D.T.,Perez Berrocal, D.A.,Mulder, M.P.C.,van der Heden van Noort, G.J.,Schulman, B.A. Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5. Nat.Chem.Biol., 20:190-200, 2024 Cited by PubMed: 37620400 DOI: 10.1038/s41589-023-01414-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.3 Å)

Structure validation