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8C07

Structure of HECT E3 UBR5 forming K48 linked Ubiquitin chains

Functional Information from GO Data
ChainGOidnamespacecontents
B0000209biological_processprotein polyubiquitination
B0000785cellular_componentchromatin
B0003723molecular_functionRNA binding
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006974biological_processDNA damage response
B0006979biological_processresponse to oxidative stress
B0008270molecular_functionzinc ion binding
B0010498biological_processproteasomal protein catabolic process
B0010628biological_processpositive regulation of gene expression
B0016020cellular_componentmembrane
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0030520biological_processestrogen receptor signaling pathway
B0032991cellular_componentprotein-containing complex
B0033696biological_processheterochromatin boundary formation
B0034450molecular_functionubiquitin-ubiquitin ligase activity
B0035519biological_processprotein K29-linked ubiquitination
B0042307biological_processpositive regulation of protein import into nucleus
B0043130molecular_functionubiquitin binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0045879biological_processnegative regulation of smoothened signaling pathway
B0046872molecular_functionmetal ion binding
B0048384biological_processretinoic acid receptor signaling pathway
B0048471cellular_componentperinuclear region of cytoplasm
B0050847biological_processprogesterone receptor signaling pathway
B0061630molecular_functionubiquitin protein ligase activity
B0070561biological_processvitamin D receptor signaling pathway
B0070936biological_processprotein K48-linked ubiquitination
B0070979biological_processprotein K11-linked ubiquitination
B0071629biological_processcytoplasm protein quality control by the ubiquitin-proteasome system
B0071630biological_processnuclear protein quality control by the ubiquitin-proteasome system
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0140455biological_processcytoplasm protein quality control
B0140861biological_processDNA repair-dependent chromatin remodeling
B0141198biological_processprotein branched polyubiquitination
J0000209biological_processprotein polyubiquitination
J0000785cellular_componentchromatin
J0003723molecular_functionRNA binding
J0004842molecular_functionubiquitin-protein transferase activity
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006281biological_processDNA repair
J0006974biological_processDNA damage response
J0006979biological_processresponse to oxidative stress
J0008270molecular_functionzinc ion binding
J0010498biological_processproteasomal protein catabolic process
J0010628biological_processpositive regulation of gene expression
J0016020cellular_componentmembrane
J0016567biological_processprotein ubiquitination
J0016740molecular_functiontransferase activity
J0030520biological_processestrogen receptor signaling pathway
J0032991cellular_componentprotein-containing complex
J0033696biological_processheterochromatin boundary formation
J0034450molecular_functionubiquitin-ubiquitin ligase activity
J0035519biological_processprotein K29-linked ubiquitination
J0042307biological_processpositive regulation of protein import into nucleus
J0043130molecular_functionubiquitin binding
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0045879biological_processnegative regulation of smoothened signaling pathway
J0046872molecular_functionmetal ion binding
J0048384biological_processretinoic acid receptor signaling pathway
J0048471cellular_componentperinuclear region of cytoplasm
J0050847biological_processprogesterone receptor signaling pathway
J0061630molecular_functionubiquitin protein ligase activity
J0070561biological_processvitamin D receptor signaling pathway
J0070936biological_processprotein K48-linked ubiquitination
J0070979biological_processprotein K11-linked ubiquitination
J0071629biological_processcytoplasm protein quality control by the ubiquitin-proteasome system
J0071630biological_processnuclear protein quality control by the ubiquitin-proteasome system
J0090263biological_processpositive regulation of canonical Wnt signaling pathway
J0140455biological_processcytoplasm protein quality control
J0140861biological_processDNA repair-dependent chromatin remodeling
J0141198biological_processprotein branched polyubiquitination
Functional Information from PROSITE/UniProt
site_idPS00299
Number of Residues26
DetailsUBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGcqleD
ChainResidueDetails
ILYS27-ASP52
KLYS27-ASP52

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Interacts with activating enzyme
ChainResidueDetails
KARG54
KARG72

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Essential for function
ChainResidueDetails
KHIS68
JCYS2768

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291
ChainResidueDetails
KSER65
BCYS1234
BCYS1240
JCYS1179
JCYS1196
JCYS1199
JCYS1208
JCYS1211
JCYS1215
JHIS1216
JHIS1219
BCYS1196
JCYS1232
JCYS1234
JCYS1240
BCYS1199
BCYS1208
BCYS1211
BCYS1215
BHIS1216
BHIS1219
BCYS1232

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457
ChainResidueDetails
KTHR66
JTHR2

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: ADP-ribosylglycine => ECO:0000269|PubMed:28525742
ChainResidueDetails
KGLY76
BSER578
BSER612
BSER808
JSER110
JSER578
JSER612
JSER808

site_idSWS_FT_FI6
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603
ChainResidueDetails
KLYS6
JSER327

site_idSWS_FT_FI7
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
ChainResidueDetails
BSER352
BSER2026
BSER2028
BSER2076
BSER2289
BSER2484
JSER352
JSER928
JSER1018
JSER1227
JSER1355
KGLY76
JSER1375
JSER1481
JSER1741
JSER1780
JSER2026
JSER2028
JSER2076
JSER2289
JSER2484
BSER1018
BSER1227
BSER1355
BSER1375
BSER1481
BSER1741
BSER1780

site_idSWS_FT_FI8
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144
ChainResidueDetails
KLYS11
JTHR1736
JTHR2030
JTHR2213
KLYS48
BTHR1135
BTHR1736
BTHR2030
BTHR2213
JTHR637
JTHR1115
JTHR1135

site_idSWS_FT_FI9
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860
ChainResidueDetails
KLYS27
JSER1308

site_idSWS_FT_FI10
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127
ChainResidueDetails
KLYS29
JSER1549

site_idSWS_FT_FI11
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577
ChainResidueDetails
KLYS33
JTYR1746

site_idSWS_FT_FI12
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106
ChainResidueDetails
KLYS63
JTHR1969

site_idSWS_FT_FI13
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER1990
JSER1990

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER2241
BSER2469
JSER2241
JSER2469

site_idSWS_FT_FI15
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER2486
JSER2486

237735

PDB entries from 2025-06-18

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