8C07

Structure of HECT E3 UBR5 forming K48 linked Ubiquitin chains

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000209	biological_process	protein polyubiquitination
B	0000785	cellular_component	chromatin
B	0003723	molecular_function	RNA binding
B	0004842	molecular_function	ubiquitin-protein transferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006974	biological_process	DNA damage response
B	0008270	molecular_function	zinc ion binding
B	0010498	biological_process	proteasomal protein catabolic process
B	0010628	biological_process	positive regulation of gene expression
B	0016020	cellular_component	membrane
B	0016567	biological_process	protein ubiquitination
B	0016740	molecular_function	transferase activity
B	0032991	cellular_component	protein-containing complex
B	0033696	biological_process	heterochromatin boundary formation
B	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
B	0035519	biological_process	protein K29-linked ubiquitination
B	0042307	biological_process	positive regulation of protein import into nucleus
B	0043130	molecular_function	ubiquitin binding
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0045879	biological_process	negative regulation of smoothened signaling pathway
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0050847	biological_process	progesterone receptor signaling pathway
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0070936	biological_process	protein K48-linked ubiquitination
B	0070979	biological_process	protein K11-linked ubiquitination
B	0071629	biological_process	cytoplasm protein quality control by the ubiquitin-proteasome system
B	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
B	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
B	0140455	biological_process	cytoplasm protein quality control
B	0140861	biological_process	DNA repair-dependent chromatin remodeling
B	0141198	biological_process	protein branched polyubiquitination
J	0000209	biological_process	protein polyubiquitination
J	0000785	cellular_component	chromatin
J	0003723	molecular_function	RNA binding
J	0004842	molecular_function	ubiquitin-protein transferase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005654	cellular_component	nucleoplasm
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006281	biological_process	DNA repair
J	0006974	biological_process	DNA damage response
J	0008270	molecular_function	zinc ion binding
J	0010498	biological_process	proteasomal protein catabolic process
J	0010628	biological_process	positive regulation of gene expression
J	0016020	cellular_component	membrane
J	0016567	biological_process	protein ubiquitination
J	0016740	molecular_function	transferase activity
J	0032991	cellular_component	protein-containing complex
J	0033696	biological_process	heterochromatin boundary formation
J	0034450	molecular_function	ubiquitin-ubiquitin ligase activity
J	0035519	biological_process	protein K29-linked ubiquitination
J	0042307	biological_process	positive regulation of protein import into nucleus
J	0043130	molecular_function	ubiquitin binding
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0045879	biological_process	negative regulation of smoothened signaling pathway
J	0046872	molecular_function	metal ion binding
J	0048471	cellular_component	perinuclear region of cytoplasm
J	0050847	biological_process	progesterone receptor signaling pathway
J	0061630	molecular_function	ubiquitin protein ligase activity
J	0070936	biological_process	protein K48-linked ubiquitination
J	0070979	biological_process	protein K11-linked ubiquitination
J	0071629	biological_process	cytoplasm protein quality control by the ubiquitin-proteasome system
J	0071630	biological_process	nuclear protein quality control by the ubiquitin-proteasome system
J	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
J	0140455	biological_process	cytoplasm protein quality control
J	0140861	biological_process	DNA repair-dependent chromatin remodeling
J	0141198	biological_process	protein branched polyubiquitination

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGcqleD

Chain	Residue	Details
I	LYS27-ASP52
K	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00104","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11287654","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23027739","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28689657","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37040767","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37478862","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"37620400","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21924388","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21924388","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	42
Details	Domain: {"description":"UBA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00212","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17897937","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37040767","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37409633","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37620400","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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