6FYH

Disulfide between ubiquitin G76C and the E3 HECT ligase Huwe1

Summary for 6FYH

• Entry DOI: 10.2210/pdb6fyh/pdb
• Descriptor: E3 ubiquitin-protein ligase HUWE1, Polyubiquitin-B, SULFATE ION, ... (5 entities in total)
• Functional Keywords: huwe1 hect, ubiquitin transfer, thioester, ligase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 23406.44

Authors

Jaeckl, M.,Hartmann, M.D.,Wiesner, S. (deposition date: 2018-03-12, release date: 2018-07-11, Last modification date: 2024-01-17)

• Primary citation: Jackl, M.,Stollmaier, C.,Strohaker, T.,Hyz, K.,Maspero, E.,Polo, S.,Wiesner, S.; beta-Sheet Augmentation Is a Conserved Mechanism of Priming HECT E3 Ligases for Ubiquitin Ligation.; J. Mol. Biol., 430:3218-3233, 2018; PubMed: 29964046; DOI: 10.1016/j.jmb.2018.06.044

Experimental method

X-RAY DIFFRACTION (2.906 Å)