6FYH

Disulfide between ubiquitin G76C and the E3 HECT ligase Huwe1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue SO4 A 401

Chain	Residue
A	ILE268
A	ILE268
A	ILE270
A	ILE270
A	ARG297
A	ARG297
A	ARG304
A	ARG304

---

site_id	AC2
Number of Residues	3
Details	binding site for residue ZN A 402

Chain	Residue
A	HIS369
A	HOH503
A	GLU365

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 403

Chain	Residue
A	HIS280
A	HIS337
A	GLU365
A	ZN406

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 404

Chain	Residue
A	HIS350
A	ASP357
A	SO4405
A	HOH502

---

site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 A 405

Chain	Residue
A	ARG341
A	HIS350
A	ASP357
A	GLU362
A	LYS366
A	ZN404
B	ZN101

---

site_id	AC6
Number of Residues	5
Details	binding site for residue ZN A 406

Chain	Residue
A	HIS280
A	HIS337
A	GLU365
A	ZN403
A	HOH505

---

site_id	AC7
Number of Residues	1
Details	binding site for residue ZN B 101

Chain	Residue
A	SO4405

---

site_id	AC8
Number of Residues	1
Details	binding site for residue ZN B 102

Chain	Residue
B	ASP32

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
B	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Glycyl thioester intermediate"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P51593","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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