7AQF
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1LJ5
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6ZRV
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![BU of 6zrv by Molmil](/molmil-images/mine/6zrv) | Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with an Inhibitory Nanobody (VHH-s-a93, Nb93) | Descriptor: | Plasminogen activator inhibitor 1, VHH-s-a93 (Nb93) | Authors: | Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. | Deposit date: | 2020-07-15 | Release date: | 2020-08-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity. Int J Mol Sci, 21, 2020
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1A7C
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![BU of 1a7c by Molmil](/molmil-images/mine/1a7c) | HUMAN PLASMINOGEN ACTIVATOR INHIBITOR TYPE-1 IN COMPLEX WITH A PENTAPEPTIDE | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-D-ribopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, PENTAPEPTIDE, ... | Authors: | Xue, Y, Inghardt, T, Sjolin, L, Deinum, J. | Deposit date: | 1998-03-12 | Release date: | 1999-03-23 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide Structure, 6, 1998
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3CVM
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6GWN
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![BU of 6gwn by Molmil](/molmil-images/mine/6gwn) | Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) | Descriptor: | Plasminogen activator inhibitor 1, VHH-2g-42, VHH-2w-64 | Authors: | Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. | Deposit date: | 2018-06-25 | Release date: | 2020-01-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18, 2020
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1DVN
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4G8R
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![BU of 4g8r by Molmil](/molmil-images/mine/4g8r) | Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1 | Descriptor: | (2S)-3-({[3-(trifluoromethyl)phenoxy]carbonyl}amino)propane-1,2-diyl bis(3,4,5-trihydroxybenzoate), Plasminogen activator inhibitor-1, SULFATE ION | Authors: | Stuckey, J.A, Lawrence, D.A, Li, S.-H. | Deposit date: | 2012-07-23 | Release date: | 2013-12-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.19 Å) | Cite: | Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. Proc.Natl.Acad.Sci.USA, 110, 2013
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7AQG
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![BU of 7aqg by Molmil](/molmil-images/mine/7aqg) | Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) | Descriptor: | 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid, Plasminogen activator inhibitor 1, VHH-2g-42 (Nb42), ... | Authors: | Sillen, M, Strelkov, S.V, Declerck, P.J. | Deposit date: | 2020-10-21 | Release date: | 2021-02-24 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484. Int J Mol Sci, 22, 2021
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1OC0
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![BU of 1oc0 by Molmil](/molmil-images/mine/1oc0) | plasminogen activator inhibitor-1 complex with somatomedin B domain of vitronectin | Descriptor: | PLASMINOGEN ACTIVATOR INHIBITOR-1, VITRONECTIN | Authors: | Read, R.J, Zhou, A, Huntington, J.A, Pannu, N.S, Carrell, R.W. | Deposit date: | 2003-02-03 | Release date: | 2003-06-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | How Vitronectin Binds Pai-1 to Modulate Fibrinolysis and Cell Migration Nat.Struct.Biol., 10, 2003
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6GWP
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![BU of 6gwp by Molmil](/molmil-images/mine/6gwp) | Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64) | Descriptor: | Plasminogen Activator Inhibitor-1, VHH-2g-42, VHH-2w-64 | Authors: | Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. | Deposit date: | 2018-06-25 | Release date: | 2020-01-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18, 2020
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3Q02
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3PB1
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![BU of 3pb1 by Molmil](/molmil-images/mine/3pb1) | Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and Urokinase-type Plasminogen Activator | Descriptor: | Plasminogen activator inhibitor 1, Plasminogen activator, urokinase, ... | Authors: | Lin, Z, Jiang, L, Huang, M, Structure 2 Function Project (S2F) | Deposit date: | 2010-10-20 | Release date: | 2010-12-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J.Biol.Chem., 286, 2011
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4IC0
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![BU of 4ic0 by Molmil](/molmil-images/mine/4ic0) | Crystal Structure of PAI-1 in Complex with Gallate | Descriptor: | 3,4,5-trihydroxybenzoic acid, Plasminogen activator inhibitor 1 | Authors: | Hong, Z.B, Lin, Z.H, Gong, L.H, Huang, M.D. | Deposit date: | 2012-12-09 | Release date: | 2013-12-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Crystal Structure of PAI-1 in Complex with Gallate To be Published
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6GWQ
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![BU of 6gwq by Molmil](/molmil-images/mine/6gwq) | Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with an Inhibitory Nanobody (VHH-2g-42) | Descriptor: | Plasminogen Activator Inhibitor-1, VHH-2g-42 | Authors: | Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J. | Deposit date: | 2018-06-25 | Release date: | 2020-01-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18, 2020
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4AQH
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![BU of 4aqh by Molmil](/molmil-images/mine/4aqh) | Plasminogen activator inhibitor type-1 in complex with the inhibitor AZ3976 | Descriptor: | PLASMINOGEN ACTIVATOR INHIBITOR 1, TERT-BUTYL 3-[(4-OXO-3H-PYRIDO[2,3-D]PYRIMIDIN-2-YL)AMINO]AZETIDINE-1-CARBOXYLATE | Authors: | Fjellstrom, O, Deinum, J, Sjogren, T, Johansson, C, Geschwindner, S, Nerme, V, Legnehed, A, McPheat, J, Olsson, K, Bodin, C, Gustafsson, D. | Deposit date: | 2012-04-17 | Release date: | 2012-11-28 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Characterization of a Small Molecule Inhibitor of Plasminogen Activator Inhibitor Type 1 that Accelerates the Transition Into the Latent Conformation J.Biol.Chem., 288, 2013
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1DVM
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![BU of 1dvm by Molmil](/molmil-images/mine/1dvm) | ACTIVE FORM OF HUMAN PAI-1 | Descriptor: | CHLORIDE ION, PLASMINOGEN ACTIVATOR INHIBITOR-1 | Authors: | Stout, T.J, Graham, H, Buckley, D.I, Matthews, D.J. | Deposit date: | 2000-01-21 | Release date: | 2000-09-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of active and latent PAI-1: a possible stabilizing role for chloride ions. Biochemistry, 39, 2000
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3UT3
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![BU of 3ut3 by Molmil](/molmil-images/mine/3ut3) | A novel PAI-I inhibitor and its structural mechanism | Descriptor: | 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione, Plasminogen activator inhibitor 1 | Authors: | Lin, Z.H, Hong, Z.B, Shi, X.L, Hu, L.H, Andreasen, P.A, Huang, M.D. | Deposit date: | 2011-11-25 | Release date: | 2013-02-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | A novel PAI-I inhibitor and its structural mechanism To be Published
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1C5G
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![BU of 1c5g by Molmil](/molmil-images/mine/1c5g) | PLASMINOGEN ACTIVATOR INHIBITOR-1 | Descriptor: | PLASMINOGEN ACTIVATOR INHIBITOR-1 | Authors: | Goldsmith, E.J. | Deposit date: | 1999-12-07 | Release date: | 1999-12-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Engineering of plasminogen activator inhibitor-1 to reduce the rate of latency transition. Nat.Struct.Biol., 2, 1995
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3EOX
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3Q03
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9PAI
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![BU of 9pai by Molmil](/molmil-images/mine/9pai) | CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Descriptor: | PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 19-364, PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 365-397 | Authors: | Aertgeerts, K, De Bondt, H.L, De Ranter, C.J, Declerck, P.J. | Deposit date: | 1999-03-11 | Release date: | 1999-03-19 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1. Nat.Struct.Biol., 2, 1995
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3R4L
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![BU of 3r4l by Molmil](/molmil-images/mine/3r4l) | Human very long half life Plasminogen Activator Inhibitor type-1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Plasminogen activator inhibitor 1, beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Yang, J, Zheng, H, Han, Q, Skrzypczak-Jankun, E, Jankun, J. | Deposit date: | 2011-03-17 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Remarkable extension of PAI-1 half-life surprisingly brings no changes to its structure. Int.J.Mol.Med., 29, 2012
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1DB2
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![BU of 1db2 by Molmil](/molmil-images/mine/1db2) | CRYSTAL STRUCTURE OF NATIVE PLASMINOGEN ACTIVATOR INHIBITOR-1 | Descriptor: | PLASMINOGEN ACTIVATOR INHIBITOR-1 | Authors: | Nar, H, Bauer, M, Stassen, J.M, Lang, D, Gils, A, Declerck, P. | Deposit date: | 1999-11-02 | Release date: | 1999-11-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation. J.Mol.Biol., 297, 2000
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4G8O
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![BU of 4g8o by Molmil](/molmil-images/mine/4g8o) | Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1 | Descriptor: | (2S)-3-({[3-(trifluoromethyl)phenoxy]carbonyl}amino)propane-1,2-diyl bis(3,4,5-trihydroxybenzoate), 1,2-ETHANEDIOL, Plasminogen activator inhibitor 1, ... | Authors: | Stuckey, J.A, Lawrence, D.A, Li, S.-H. | Deposit date: | 2012-07-23 | Release date: | 2013-12-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. Proc.Natl.Acad.Sci.USA, 110, 2013
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