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7AQF

Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab)

Summary for 7AQF
Entry DOI10.2210/pdb7aqf/pdb
DescriptorPlasminogen activator inhibitor 1, 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid (3 entities in total)
Functional Keywordsplasminogen activator inhibitor-1, pai-1, pai-1-stab, serpin, protease inhibitor, serine protease inhibitor, small molecule inhibitor, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight85886.79
Authors
Sillen, M.,Strelkov, S.V.,Declerck, P.J. (deposition date: 2020-10-21, release date: 2021-02-17, Last modification date: 2024-01-31)
Primary citationSillen, M.,Miyata, T.,Vaughan, D.E.,Strelkov, S.V.,Declerck, P.J.
Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484.
Int J Mol Sci, 22:-, 2021
Cited by
PubMed: 33540702
DOI: 10.3390/ijms22031482
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.77 Å)
Structure validation

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