7AQF
Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab)
Summary for 7AQF
Entry DOI | 10.2210/pdb7aqf/pdb |
Descriptor | Plasminogen activator inhibitor 1, 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid (3 entities in total) |
Functional Keywords | plasminogen activator inhibitor-1, pai-1, pai-1-stab, serpin, protease inhibitor, serine protease inhibitor, small molecule inhibitor, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 85886.79 |
Authors | Sillen, M.,Strelkov, S.V.,Declerck, P.J. (deposition date: 2020-10-21, release date: 2021-02-17, Last modification date: 2024-01-31) |
Primary citation | Sillen, M.,Miyata, T.,Vaughan, D.E.,Strelkov, S.V.,Declerck, P.J. Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484. Int J Mol Sci, 22:-, 2021 Cited by PubMed: 33540702DOI: 10.3390/ijms22031482 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.77 Å) |
Structure validation
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