7AQG

Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F)

Summary for 7AQG

• Entry DOI: 10.2210/pdb7aqg/pdb
• Descriptor: Plasminogen activator inhibitor 1, VHH-2g-42 (Nb42), VHH-2w-64 (Nb64), ... (5 entities in total)
• Functional Keywords: plasminogen activator inhibitor-1, pai-1, pai-1-w175f, serpin, protease inhibitor, serine protease inhibitor, small molecule, antibody fragments, nanobodies, protein complex, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 69004.44

Authors

Sillen, M.,Strelkov, S.V.,Declerck, P.J. (deposition date: 2020-10-21, release date: 2021-02-24, Last modification date: 2024-01-31)

• Primary citation: Sillen, M.,Miyata, T.,Vaughan, D.E.,Strelkov, S.V.,Declerck, P.J.; Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484.; Int J Mol Sci, 22:-, 2021; PubMed: 33540702; DOI: 10.3390/ijms22031482

Experimental method

X-RAY DIFFRACTION (2.27 Å)