4G8R
Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1
Summary for 4G8R
Entry DOI | 10.2210/pdb4g8r/pdb |
Related | 1B3K 4G8O |
Descriptor | Plasminogen activator inhibitor-1, SULFATE ION, (2S)-3-({[3-(trifluoromethyl)phenoxy]carbonyl}amino)propane-1,2-diyl bis(3,4,5-trihydroxybenzoate), ... (4 entities in total) |
Functional Keywords | serpin, pai-1, inhibitor, blood clotting, blood clotting-inhibitor complex, blood clotting/inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P05121 |
Total number of polymer chains | 2 |
Total formula weight | 86024.04 |
Authors | Stuckey, J.A.,Lawrence, D.A.,Li, S.-H. (deposition date: 2012-07-23, release date: 2013-12-25, Last modification date: 2024-02-28) |
Primary citation | Li, S.H.,Reinke, A.A.,Sanders, K.L.,Emal, C.D.,Whisstock, J.C.,Stuckey, J.A.,Lawrence, D.A. Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. Proc.Natl.Acad.Sci.USA, 110:E4941-E4949, 2013 Cited by PubMed: 24297881DOI: 10.1073/pnas.1216499110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.19 Å) |
Structure validation
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