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4G8R

Crystal Structure of a novel small molecule inactivator bound to plasminogen activator inhibitor-1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0002020molecular_functionprotease binding
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005102molecular_functionsignaling receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0010469biological_processregulation of signaling receptor activity
A0010757biological_processnegative regulation of plasminogen activation
A0010951biological_processnegative regulation of endopeptidase activity
A0014912biological_processnegative regulation of smooth muscle cell migration
A0030194biological_processpositive regulation of blood coagulation
A0030195biological_processnegative regulation of blood coagulation
A0030336biological_processnegative regulation of cell migration
A0031093cellular_componentplatelet alpha granule lumen
A0032757biological_processpositive regulation of interleukin-8 production
A0033629biological_processnegative regulation of cell adhesion mediated by integrin
A0035491biological_processpositive regulation of leukotriene production involved in inflammatory response
A0042730biological_processfibrinolysis
A0045766biological_processpositive regulation of angiogenesis
A0048260biological_processpositive regulation of receptor-mediated endocytosis
A0050729biological_processpositive regulation of inflammatory response
A0050829biological_processdefense response to Gram-negative bacterium
A0051918biological_processnegative regulation of fibrinolysis
A0061044biological_processnegative regulation of vascular wound healing
A0061045biological_processnegative regulation of wound healing
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0071222biological_processcellular response to lipopolysaccharide
A0090026biological_processpositive regulation of monocyte chemotaxis
A0090399biological_processreplicative senescence
A0097180cellular_componentserine protease inhibitor complex
A0097187biological_processdentinogenesis
A1901331biological_processpositive regulation of odontoblast differentiation
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1904090cellular_componentpeptidase inhibitor complex
A2000098biological_processnegative regulation of smooth muscle cell-matrix adhesion
A2000352biological_processnegative regulation of endothelial cell apoptotic process
B0001525biological_processangiogenesis
B0002020molecular_functionprotease binding
B0004867molecular_functionserine-type endopeptidase inhibitor activity
B0005102molecular_functionsignaling receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0010469biological_processregulation of signaling receptor activity
B0010757biological_processnegative regulation of plasminogen activation
B0010951biological_processnegative regulation of endopeptidase activity
B0014912biological_processnegative regulation of smooth muscle cell migration
B0030194biological_processpositive regulation of blood coagulation
B0030195biological_processnegative regulation of blood coagulation
B0030336biological_processnegative regulation of cell migration
B0031093cellular_componentplatelet alpha granule lumen
B0032757biological_processpositive regulation of interleukin-8 production
B0033629biological_processnegative regulation of cell adhesion mediated by integrin
B0035491biological_processpositive regulation of leukotriene production involved in inflammatory response
B0042730biological_processfibrinolysis
B0045766biological_processpositive regulation of angiogenesis
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0050729biological_processpositive regulation of inflammatory response
B0050829biological_processdefense response to Gram-negative bacterium
B0051918biological_processnegative regulation of fibrinolysis
B0061044biological_processnegative regulation of vascular wound healing
B0061045biological_processnegative regulation of wound healing
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0071222biological_processcellular response to lipopolysaccharide
B0090026biological_processpositive regulation of monocyte chemotaxis
B0090399biological_processreplicative senescence
B0097180cellular_componentserine protease inhibitor complex
B0097187biological_processdentinogenesis
B1901331biological_processpositive regulation of odontoblast differentiation
B1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
B1904090cellular_componentpeptidase inhibitor complex
B2000098biological_processnegative regulation of smooth muscle cell-matrix adhesion
B2000352biological_processnegative regulation of endothelial cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 B 401
ChainResidue
AHIS10
BSER119
BTHR120
BLYS122
BTRP139

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE 96P B 402
ChainResidue
AARG131
APHE134
AILE135
AASP138
BSER6
BTYR7
BHIS10
APRO111
APHE114
AARG115
AARG118

site_idAC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE 96P B 403
ChainResidue
AHIS10
AGLN257
ASER260
AHIS261
BSER41
BMET45
BLEU75
BARG76
BTYR79
BASP95
BPHE117
BARG118
BHOH594

Functional Information from PROSITE/UniProt
site_idPS00284
Number of Residues11
DetailsSERPIN Serpins signature. IIIDRPFLFvV
ChainResidueDetails
AILE352-VAL362

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Reactive bond
ChainResidueDetails
AARG346
BARG346

site_idSWS_FT_FI2
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
AASN209
AASN265
BASN209
BASN265

site_idSWS_FT_FI3
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN329
BASN329

221051

PDB entries from 2024-06-12

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