6GWP

Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)

Summary for 6GWP

Entry DOI	10.2210/pdb6gwp/pdb
Descriptor	Plasminogen Activator Inhibitor-1, VHH-2g-42, VHH-2w-64, ... (4 entities in total)
Functional Keywords	plasminogen activator inhibitor-1, pai-1, pai-1-stab, serpin, protease inhibitor, serine protease inhibitor, nanobody, antibody fragment, protein complex, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	68590.65
Authors	Sillen, M.,Weeks, S.D.,Strelkov, S.V.,Declerck, P.J. (deposition date: 2018-06-25, release date: 2020-01-01, Last modification date: 2024-01-17)
Primary citation	Sillen, M.,Weeks, S.D.,Zhou, X.,Komissarov, A.A.,Florova, G.,Idell, S.,Strelkov, S.V.,Declerck, P.J. Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction. J.Thromb.Haemost., 18:681-692, 2020 Cited by PubMed: 31858714 DOI: 10.1111/jth.14716 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.28 Å)

Structure validation