3Q03

Crystal structure of plasminogen activator inhibitor-1 in a metastable active conformation.

Summary for 3Q03

Entry DOI	10.2210/pdb3q03/pdb
Related	1B3K 1DB2 1DVM
Descriptor	Plasminogen activator inhibitor 1, ZINC ION, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	pai-1, active serpin, serine protease inhibitor, metastable conformation, hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Secreted: P05121
Total number of polymer chains	2
Total formula weight	85761.79
Authors	Jensen, J.K.,Morth, J.P. (deposition date: 2010-12-15, release date: 2011-06-22, Last modification date: 2023-09-13)
Primary citation	Jensen, J.K.,Thompson, L.C.,Bucci, J.C.,Nissen, P.,Gettins, P.G.,Peterson, C.B.,Andreasen, P.A.,Morth, J.P. Crystal structure of plasminogen activator inhibitor-1 in an active conformation with normal thermodynamic stability. J.Biol.Chem., 286:29709-29717, 2011 Cited by PubMed: 21697084 DOI: 10.1074/jbc.M111.236554 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6401 Å)

Structure validation