3PB1

Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and Urokinase-type Plasminogen Activator

Summary for 3PB1

Entry DOI	10.2210/pdb3pb1/pdb
Related	1DVM 2O8T
Descriptor	Plasminogen activator inhibitor 1, Plasminogen activator, urokinase, SULFATE ION, ... (4 entities in total)
Functional Keywords	pai-1, upa, michaelis complex, structural genomics, structure 2 function project, s2f, hydrolase inhibitor-hydrolase complex, hydrolase inhibitor/hydrolase
Biological source	Homo sapiens (human) More
Cellular location	Secreted: P05121
Total number of polymer chains	2
Total formula weight	71413.57
Authors	Lin, Z.,Jiang, L.,Huang, M.,Structure 2 Function Project (S2F) (deposition date: 2010-10-20, release date: 2010-12-29, Last modification date: 2023-11-01)
Primary citation	Lin, Z.,Jiang, L.,Yuan, C.,Jensen, J.K.,Zhang, X.,Luo, Z.,Furie, B.C.,Furie, B.,Andreasen, P.A.,Huang, M. Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. J.Biol.Chem., 286:7027-7032, 2011 Cited by PubMed: 21199867 DOI: 10.1074/jbc.M110.204537 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation