3PB1
Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and Urokinase-type Plasminogen Activator
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | I | Plasminogen activator inhibitor 1 | polymer | 379 | 42795.1 | 1 | UniProt (P05121) Pfam (PF00079) In PDB | Homo sapiens (human) | PAI, PAI-1, Endothelial plasminogen activator inhibitor, Serpin E1 |
2 | E | Plasminogen activator, urokinase | polymer | 253 | 28426.4 | 1 | UniProt (Q5SWW8) Pfam (PF00089) UniProt (by SIFTS) (P00749) In PDB | Homo sapiens (human) | |
3 | E | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
4 | water | water | 18.0 | 314 | Chemie (HOH) |
Sequence modifications
I: 1 - 379 (UniProt: P05121)
E: 16 - 250 (UniProt: Q5SWW8)
PDB | External Database | Details |
---|---|---|
His 150 | Asn 173 | engineered mutation |
Thr 154 | Lys 177 | engineered mutation |
Gln 158 | Asp 181 | conflict |
Leu 319 | Gln 342 | engineered mutation |
Ile 354 | Met 377 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ala 122 | Cys 263 | conflict |
Gln 145 | Asn 286 | conflict |
Ala 195 | Ser 340 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 71221.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 192.1 | |
All* | Total formula weight | 71413.6 |