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3PB1

Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and Urokinase-type Plasminogen Activator

Functional Information from GO Data
ChainGOidnamespacecontents
E0004252molecular_functionserine-type endopeptidase activity
E0006508biological_processproteolysis
I0001525biological_processangiogenesis
I0002020molecular_functionprotease binding
I0004867molecular_functionserine-type endopeptidase inhibitor activity
I0005102molecular_functionsignaling receptor binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005615cellular_componentextracellular space
I0005886cellular_componentplasma membrane
I0010469biological_processregulation of signaling receptor activity
I0010757biological_processnegative regulation of plasminogen activation
I0010951biological_processnegative regulation of endopeptidase activity
I0014912biological_processnegative regulation of smooth muscle cell migration
I0030194biological_processpositive regulation of blood coagulation
I0030195biological_processnegative regulation of blood coagulation
I0030336biological_processnegative regulation of cell migration
I0031093cellular_componentplatelet alpha granule lumen
I0032757biological_processpositive regulation of interleukin-8 production
I0033629biological_processnegative regulation of cell adhesion mediated by integrin
I0035491biological_processpositive regulation of leukotriene production involved in inflammatory response
I0042730biological_processfibrinolysis
I0045766biological_processpositive regulation of angiogenesis
I0048260biological_processpositive regulation of receptor-mediated endocytosis
I0050729biological_processpositive regulation of inflammatory response
I0050829biological_processdefense response to Gram-negative bacterium
I0051918biological_processnegative regulation of fibrinolysis
I0061044biological_processnegative regulation of vascular wound healing
I0061045biological_processnegative regulation of wound healing
I0062023cellular_componentcollagen-containing extracellular matrix
I0070062cellular_componentextracellular exosome
I0071222biological_processcellular response to lipopolysaccharide
I0090026biological_processpositive regulation of monocyte chemotaxis
I0090399biological_processreplicative senescence
I0097180cellular_componentserine protease inhibitor complex
I0097187biological_processdentinogenesis
I1901331biological_processpositive regulation of odontoblast differentiation
I1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
I1904090cellular_componentpeptidase inhibitor complex
I2000098biological_processnegative regulation of smooth muscle cell-matrix adhesion
I2000352biological_processnegative regulation of endothelial cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 E 1
ChainResidue
ESER48
EPRO49
ECYS50
ETRP51
IARG30
IHOH497

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 E 2
ChainResidue
ESER125
EMET126
EARG239

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC
ChainResidueDetails
EILE53-CYS58

site_idPS00284
Number of Residues11
DetailsSERPIN Serpins signature. IIIDRPFLFvV
ChainResidueDetails
IILE352-VAL362

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system
ChainResidueDetails
EHIS57
EASP102
EALA195

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:9151681
ChainResidueDetails
ESER146
IASN265

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine
ChainResidueDetails
EGLN145

222415

PDB entries from 2024-07-10

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