6ZRV

Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with an Inhibitory Nanobody (VHH-s-a93, Nb93)

Summary for 6ZRV

• Entry DOI: 10.2210/pdb6zrv/pdb
• Descriptor: Plasminogen activator inhibitor 1, VHH-s-a93 (Nb93) (3 entities in total)
• Functional Keywords: plasminogen activator inhibitor-1, pai-1, pai-1-w175f, serpin, serine protease inhibitor, nanobody, antibody fragment, protein complex, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 56032.46

Authors

Sillen, M.,Weeks, S.D.,Strelkov, S.V.,Declerck, P.J. (deposition date: 2020-07-15, release date: 2020-08-26, Last modification date: 2024-01-31)

• Primary citation: Sillen, M.,Weeks, S.D.,Strelkov, S.V.,Declerck, P.J.; Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity.; Int J Mol Sci, 21:-, 2020; PubMed: 32824134; DOI: 10.3390/ijms21165859

Experimental method

X-RAY DIFFRACTION (1.88 Å)