6ZRV
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with an Inhibitory Nanobody (VHH-s-a93, Nb93)
Summary for 6ZRV
Entry DOI | 10.2210/pdb6zrv/pdb |
Descriptor | Plasminogen activator inhibitor 1, VHH-s-a93 (Nb93) (3 entities in total) |
Functional Keywords | plasminogen activator inhibitor-1, pai-1, pai-1-w175f, serpin, serine protease inhibitor, nanobody, antibody fragment, protein complex, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 56032.46 |
Authors | Sillen, M.,Weeks, S.D.,Strelkov, S.V.,Declerck, P.J. (deposition date: 2020-07-15, release date: 2020-08-26, Last modification date: 2024-01-31) |
Primary citation | Sillen, M.,Weeks, S.D.,Strelkov, S.V.,Declerck, P.J. Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity. Int J Mol Sci, 21:-, 2020 Cited by PubMed: 32824134DOI: 10.3390/ijms21165859 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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