6ZRV
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with an Inhibitory Nanobody (VHH-s-a93, Nb93)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Plasminogen activator inhibitor 1 | polymer | 379 | 42780.0 | 1 | UniProt (P05121) Pfam (PF00079) | Homo sapiens (Human) | PAI-1,Endothelial plasminogen activator inhibitor,Serpin E1 |
| 2 | B (B) | VHH-s-a93 (Nb93) | polymer | 123 | 13252.4 | 1 | Vicugna pacos (Alpaca) | ||
| 3 | C, D (A, B) | water | water | 18.0 | 315 | Chemie (HOH) |
Sequence modifications
A: 1 - 379 (UniProt: P05121)
| PDB | External Database | Details |
|---|---|---|
| Phe 175 | Trp 198 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 56032.5 | |
| All* | Total formula weight | 56032.5 |
