2MOX
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![BU of 2mox by Molmil](/molmil-images/mine/2mox) | solution structure of tandem SH3 domain of Sorbin and SH3 domain-containing protein 1 | Descriptor: | Sorbin and SH3 domain-containing protein 1 | Authors: | Zhao, D, Wang, C, Zhang, J, Wu, J, Shi, Y, Zhang, Z, Gong, Q. | Deposit date: | 2014-05-07 | Release date: | 2014-05-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural investigation of the interaction between the tandem SH3 domains of c-Cbl-associated protein and vinculin J.Struct.Biol., 187, 2014
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2L3S
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![BU of 2l3s by Molmil](/molmil-images/mine/2l3s) | Structure of the autoinhibited Crk | Descriptor: | Autoinhibited Crk protein | Authors: | Kalodimos, C.G, Sarkar, P, Saleh, T, Tzeng, S.R, Birge, R. | Deposit date: | 2010-09-21 | Release date: | 2010-12-08 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural basis for regulation of the Crk signaling protein by a proline switch. Nat.Chem.Biol., 7, 2011
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2PZ1
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![BU of 2pz1 by Molmil](/molmil-images/mine/2pz1) | Crystal Structure of Auto-inhibited Asef | Descriptor: | Rho guanine nucleotide exchange factor 4 | Authors: | Betts, L, Sondek, J, Rossman, K.L. | Deposit date: | 2007-05-17 | Release date: | 2007-08-21 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression. Nat.Struct.Mol.Biol., 14, 2007
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2LZ6
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![BU of 2lz6 by Molmil](/molmil-images/mine/2lz6) | Distinct ubiquitin binding modes exhibited by sh3 domains: molecular determinants and functional implications | Descriptor: | CD2-associated protein, Ubiquitin | Authors: | Ortega-Roldan, J, Azuaga, A, Blackledge, M, Van Nuland, N. | Deposit date: | 2012-09-24 | Release date: | 2013-10-02 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Distinct Ubiquitin Binding Modes Exhibited by SH3 Domains: Molecular Determinants and Functional Implications. Plos One, 8, 2013
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1W70
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![BU of 1w70 by Molmil](/molmil-images/mine/1w70) | SH3 domain of p40phox complexed with C-terminal polyProline region of p47phox | Descriptor: | NEUTROPHIL CYTOSOL FACTOR 1, NEUTROPHIL CYTOSOL FACTOR 4, SULFATE ION, ... | Authors: | Massenet, C, Chenavas, S, Cohen-Addad, C, Dagher, M.-C, Brandolin, G, Pebay-Peyroula, E, Fieschi, F. | Deposit date: | 2004-08-26 | Release date: | 2005-01-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.46 Å) | Cite: | Effects of P47Phox C-Terminus Phosphorylation on Binding Interactions with P40Phox and P67Phox: Structural and Functional Comparison of P40Phox P67Phox SH3 Domains J.Biol.Chem., 280, 2005
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1YCS
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![BU of 1ycs by Molmil](/molmil-images/mine/1ycs) | P53-53BP2 COMPLEX | Descriptor: | 53BP2, P53, ZINC ION | Authors: | Gorina, S, Pavletich, N.P. | Deposit date: | 1996-09-30 | Release date: | 1997-11-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Science, 274, 1996
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2JT4
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2DX1
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![BU of 2dx1 by Molmil](/molmil-images/mine/2dx1) | Crystal structure of RhoGEF protein Asef | Descriptor: | Rho guanine nucleotide exchange factor 4 | Authors: | Murayama, K, Kato-Murayama, M, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-08-22 | Release date: | 2007-01-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism J.Biol.Chem., 282, 2007
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2DYB
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![BU of 2dyb by Molmil](/molmil-images/mine/2dyb) | The crystal structure of human p40(phox) | Descriptor: | Neutrophil cytosol factor 4 | Authors: | Honbou, K. | Deposit date: | 2006-09-08 | Release date: | 2007-01-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding. Embo J., 26, 2007
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6PBC
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![BU of 6pbc by Molmil](/molmil-images/mine/6pbc) | Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION | Authors: | Hajicek, N, Sondek, J. | Deposit date: | 2019-06-13 | Release date: | 2020-01-08 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations. Elife, 8, 2019
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8SSN
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![BU of 8ssn by Molmil](/molmil-images/mine/8ssn) | Abl kinase in complex with SKI and asciminib | Descriptor: | 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine, CHLORIDE ION, DIMETHYL SULFOXIDE, ... | Authors: | Ludewig, H, Kim, C, Kern, D. | Deposit date: | 2023-05-08 | Release date: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.86 Å) | Cite: | A biophysical framework for double-drugging kinases. Proc.Natl.Acad.Sci.USA, 120, 2023
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4M4Z
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4LUD
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![BU of 4lud by Molmil](/molmil-images/mine/4lud) | Crystal Structure of HCK in complex with the fluorescent compound SKF86002 | Descriptor: | 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b][1,3]thiazole, CALCIUM ION, CHLORIDE ION, ... | Authors: | Parker, L.J, Tanaka, A, Handa, N, Honda, K, Tomabechi, Y, Shirouzu, M, Yokoyama, S. | Deposit date: | 2013-07-25 | Release date: | 2014-02-12 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002. Acta Crystallogr.,Sect.D, 70, 2014
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8DGQ
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8DGO
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8GMB
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![BU of 8gmb by Molmil](/molmil-images/mine/8gmb) | Crystal structure of the full-length Bruton's tyrosine kinase (PH-TH domain not visible) | Descriptor: | 2-[3'-(hydroxymethyl)-1-methyl-5-({5-[(2S)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl}amino)-6-oxo[1,6-dihydro[3,4'-bipyridine]]-2'-yl]-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one, Tyrosine-protein kinase BTK | Authors: | Lin, D.Y, Andreotti, A.H. | Deposit date: | 2023-03-24 | Release date: | 2023-08-16 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Conformational heterogeneity of the BTK PHTH domain drives multiple regulatory states. Elife, 12, 2024
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4XI2
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4D8K
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6F3F
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![BU of 6f3f by Molmil](/molmil-images/mine/6f3f) | Autoinhibited Src kinase bound to ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Tyrosine-protein kinase | Authors: | von Raussendorf, F, Leonard, T.A. | Deposit date: | 2017-11-28 | Release date: | 2017-12-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.41795778 Å) | Cite: | A switch in nucleotide affinity governs activation of the Src and Tec family kinases. Sci Rep, 7, 2017
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7Z3J
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![BU of 7z3j by Molmil](/molmil-images/mine/7z3j) | Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate | Descriptor: | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | Authors: | Pinotsis, N, Bunney, T.D, Katan, M. | Deposit date: | 2022-03-02 | Release date: | 2022-07-20 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme. Sci Adv, 8, 2022
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7YQE
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1QCF
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![BU of 1qcf by Molmil](/molmil-images/mine/1qcf) | CRYSTAL STRUCTURE OF HCK IN COMPLEX WITH A SRC FAMILY-SELECTIVE TYROSINE KINASE INHIBITOR | Descriptor: | 1-TER-BUTYL-3-P-TOLYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-YLAMINE, Tyrosine-protein kinase HCK | Authors: | Schindler, T, Sicheri, F, Pico, A, Gazit, A, Levitzki, A, Kuriyan, J. | Deposit date: | 1999-05-04 | Release date: | 1999-06-08 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor. Mol.Cell, 3, 1999
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1GRI
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![BU of 1gri by Molmil](/molmil-images/mine/1gri) | GRB2 | Descriptor: | GROWTH FACTOR BOUND PROTEIN 2 | Authors: | Maignan, S, Arnoux, B, Ducruix, A. | Deposit date: | 1995-02-28 | Release date: | 1996-03-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal structure of the mammalian Grb2 adaptor. Science, 268, 1995
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8JN8
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8JN9
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