6PBC

Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations

Summary for 6PBC

Entry DOI	10.2210/pdb6pbc/pdb
Descriptor	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma,1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, CALCIUM ION, SODIUM ION, ... (4 entities in total)
Functional Keywords	1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-1, hydrolase
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	1
Total formula weight	136019.99
Authors	Hajicek, N.,Sondek, J. (deposition date: 2019-06-13, release date: 2020-01-08, Last modification date: 2024-03-13)
Primary citation	Hajicek, N.,Keith, N.C.,Siraliev-Perez, E.,Temple, B.R.S.,Huang, W.,Zhang, Q.,Harden, T.K.,Sondek, J. Structural basis for the activation of PLC-gamma isozymes by phosphorylation and cancer-associated mutations. Elife, 8:-, 2019 Cited by PubMed: 31889510 DOI: 10.7554/eLife.51700 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.46 Å)

Structure validation